PHA刺激的淋巴细胞产生白细胞抑制因子（LIF）和巨噬细胞抑制因子（MIF）。
Production of leucocyte inhibitory factor (LIF) and macrophage inhibitory factor (MIF) by PHA-stimulated lymphocytes.
作者信息
Rabson A R, Koornhof H J
出版信息
Clin Exp Immunol. 1975 Dec;22(3):522-7.
Supernatants from human mononuclear cells cultured with PHA inhibited the migration of both human polymorphonuclear leucocytes and guinea-pig peritoneal exudate cells, but not human mononuclear cells. Using ultrafiltration it was shown that these supernatants contained two inhibiting factors, the one with a molecular weight of 15,000-50,000 inhibited only guinea-pig peritoneal exudate cells (MIF), whereas the fraction containing molecules of a size between 50,000 and 75,000 specifically inhibited the migration of polymorphonuclear leucocytes (LIF). The polymorphonuclear leucocyte inhibiting activity was heat labile. It is suggested that the leucocyte migration inhibition test is dependent upon the production of a lymphokine (LIF) which acts specifically on polymorphonuclear leucocytes causing their inhibition of migration.
用PHA培养的人单核细胞的上清液抑制人多形核白细胞和豚鼠腹腔渗出细胞的迁移，但不抑制人单核细胞的迁移。通过超滤表明，这些上清液含有两种抑制因子，一种分子量为15,000 - 50,000的因子仅抑制豚鼠腹腔渗出细胞（MIF），而含有大小在50,000至75,000之间分子的部分特异性抑制多形核白细胞的迁移（LIF）。多形核白细胞抑制活性对热不稳定。有人提出白细胞迁移抑制试验依赖于一种淋巴因子（LIF）的产生，该淋巴因子特异性作用于多形核白细胞，导致其迁移受到抑制。
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