Department of Gastroduodenal and Pancreatic Surgery, Translational Medicine Joint Research Center of Liver Cancer of Hunan University, Laboratory of Digestive Oncology, Affiliated Cancer Hospital of Xiangya Medical School & Hunan Cancer Hospital, Central South University, Changsha, China.
Institute of Pathogen Biology and Immunology of College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan University, Changsha, China.
Int J Cancer. 2023 Jan 15;152(2):110-122. doi: 10.1002/ijc.34195. Epub 2022 Jul 13.
Pancreatic cancer (PC) is a cancer of the digestive system, and pancreatic ductal adenocarcinoma (PDAC) accounts for approximately 90% of all PC cases. Exosomes derived from PDAC (PDAC-exosomes) promote PDAC development and metastasis. Exosomes are nanoscale vesicles secreted by most cells, which can carry biologically active molecules and mediate communication and cargo transportation among cells. Recent studies have focused on transforming exosomes into good drug delivery systems (DDSs) to improve the clinical treatment of PDAC. This review considers PDAC as the main research object to introduce the role of PDAC-exosomes in PDAC development and metastasis. This review focuses on the following two themes: (a) the great potential of PDAC-exosomes as new diagnostic markers for PDAC, and (b) the transformation of exosomes into potential DDSs.
胰腺癌（PC）是一种消化系统癌症，胰腺导管腺癌（PDAC）约占所有 PC 病例的 90%。源自 PDAC 的外泌体（PDAC-exosomes）促进 PDAC 的发展和转移。外泌体是大多数细胞分泌的纳米级囊泡，可携带具有生物活性的分子，并介导细胞间的通讯和货物运输。最近的研究集中在外泌体转化为良好的药物传递系统（DDS），以改善 PDAC 的临床治疗。本综述以 PDAC 为主要研究对象，介绍 PDAC-exosomes 在 PDAC 发展和转移中的作用。本综述重点关注以下两个主题：（a）PDAC-exosomes 作为 PDAC 新诊断标志物的巨大潜力，以及（b）将外泌体转化为潜在的 DDS。
