promotes osteoblast differentiation and alleviates osteoporosis via the // axis.

This study was designed to elucidate the role of and functions in postmenopausal osteoporosis. Mice were ovariectomized to establish an osteoporosis model and MC3T3-E1-14 osteoblasts were induced to differentiate. Gain- or loss-of-function approaches were used to manipulate the expression of ,  and , followed by an evaluation of their role in postmenopausal osteoporosis both and . induced methylation of the promoter region, consequently stimulating osteoblast differentiation. elevated , which decreased and inhibited osteoblast differentiation. Inhibition of reduced while increasing expression, thus alleviating postmenopausal osteoporosis in mice. promotes osteoblast differentiation and prevents postmenopausal osteoporosis by regulating the // axis.