McGinley P A, Morris J B, Clay R J, Gianutsos G
Toxicol Lett. 1987 Apr;36(2):137-45. doi: 10.1016/0378-4274(87)90177-9.
The disposition and toxicity of methylcyclopentadienyl manganese tricarbonyl (MMT) was studied in Sprague-Dawley rats after subcutaneous administration at a dose of 4 mg/kg. Blood, lung, liver and kidney Mn levels were increased between 1.5 and 96 h after MMT injection, with peak organ levels occurring at 3-6 h. At this time the MMT-derived Mn concentration in lung, liver and kidney averaged 13-, 4- and 4-fold higher, respectively, than in the blood, indicating the accumulation and retention of MMT (or metabolite) in these tissues. Maximal pulmonary toxicity, as assessed by pulmonary lavage protein levels, occurred 24-48 h after injection. Plasma urea and sorbitol dehydrogenase levels were not increased at any time after MMT, suggesting minimal or no hepatic or renal injury. That maximal pulmonary toxicity occurred after peak Mn accumulation, and that the organ-specific toxicity of MMT correlated with its accumulation and retention, suggests a causal relationship between tissue Mn accumulation and MMT-induced toxicity.
在给予Sprague-Dawley大鼠皮下注射剂量为4mg/kg的甲基环戊二烯三羰基锰（MMT）后，对其处置和毒性进行了研究。MMT注射后1.5至96小时，血液、肺、肝和肾中的锰水平升高，各器官中的锰水平在3至6小时达到峰值。此时，肺、肝和肾中源自MMT的锰浓度分别平均比血液中的高13倍、4倍和4倍，表明MMT（或代谢物）在这些组织中蓄积和滞留。通过肺灌洗蛋白水平评估，最大肺毒性在注射后24至48小时出现。MMT注射后任何时间血浆尿素和山梨醇脱氢酶水平均未升高，提示肝或肾损伤极小或未发生损伤。最大肺毒性在锰蓄积峰值后出现，且MMT的器官特异性毒性与其蓄积和滞留相关，这表明组织锰蓄积与MMT诱导的毒性之间存在因果关系。
