Komura J, Sakamoto M
Department of Environmental Science, Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa, Japan.
Arch Environ Contam Toxicol. 1992 Nov;23(4):473-5. doi: 10.1007/BF00203812.
The disposition and toxicity of methylcyclopentadienyl manganese tricarbonyl (MMT), a potential substitute for lead in gasoline, was studied to investigate the different adverse effects in ddY mice after chronic oral administration at 0.5 g/kg in food for 12 months. There was no significant difference in intake between the control mice and the mice exposed to MMT (MMT group), but those given MMT suppressed weight significantly. The manganese content in the organs of the MMT group was 4.4-1.5 times significantly higher than that of the control group. In the MMT group, the manganese content was highest in the kidney, followed by the liver, thyroid gland, sublingual gland, and prostate gland. The blood manganese level in the MMT group was about 8 times higher than that in the control group. The urinary excretion of manganese in the MMT group was 5.4% of the daily oral intake. The organometallic form of the manganese involved is apparently absorbed more readily than inorganic forms. The stronger toxicity of MMT to the tissue than that of inorganic manganese is attributed to the significantly higher blood and tissue levels of manganese in the MMT group.
研究了汽油中铅的潜在替代品甲基环戊二烯基三羰基锰（MMT）的处置和毒性，以调查在食物中按0.5 g/kg慢性口服给药12个月后对ddY小鼠产生的不同不良影响。对照小鼠和接触MMT的小鼠（MMT组）的摄入量没有显著差异，但给予MMT的小鼠体重显著减轻。MMT组器官中的锰含量比对照组显著高4.4至1.5倍。在MMT组中，肾脏中的锰含量最高，其次是肝脏、甲状腺、舌下腺和前列腺。MMT组的血锰水平比对照组高约8倍。MMT组锰的尿排泄量为每日口服摄入量的5.4%。所涉及的锰的有机金属形式显然比无机形式更容易被吸收。MMT对组织的毒性比无机锰更强，这归因于MMT组中血液和组织中的锰水平显著更高。
