Tang Catherine, Shen Yandong, Soosapilla Asha, Mulligan Stephen P
Department of Haematology and Flow Cytometry, Laverty Pathology, Sydney, Australia.
Department of Haematology, Gosford Hospital, Gosford, Australia.
Leuk Lymphoma. 2022 Dec;63(12):2795-2806. doi: 10.1080/10428194.2022.2092857. Epub 2022 Jun 29.
Since first described almost two decades ago, there has been significant evolution in our definition and understanding of the biology and implications of monoclonal B-cell lymphocytosis (MBL). This review provides an overview of the definition, classification, biology, and natural history of MBL, mainly focused on the dominant CLL-like phenotype form of MBL. The increasingly recognized implications of MBL with respect to immune dysfunction are discussed, particularly in view of the COVID-19 pandemic, along with management recommendations for MBL in the clinic.
自近二十年前首次被描述以来，我们对单克隆B细胞淋巴细胞增多症（MBL）的生物学特性及其影响的定义和理解有了显著进展。本综述概述了MBL的定义、分类、生物学特性和自然病程，主要聚焦于占主导地位的CLL样表型形式的MBL。文中讨论了MBL在免疫功能障碍方面日益受到认可的影响，特别是鉴于新冠疫情，还给出了临床中MBL的管理建议。
