Mazzi C
Minerva Med. 1979 Mar 30;70(15):1043-56.
The secretion values of the two seric gonadotropins and of plasmatic testosterone have been estimated in a casuistry of normal males subdivided in groups of 8 to 95 years of age, and of primitive and secondary testicular dyschrinia. In one part of this casuistry, normal and primitive hypogonadics, we have estimated the response to the intravenous administration of Gn-RH. Among the results which have been obtained, it appears that physiologic hypogonadism of the elderly is a primary phenomenum, not hypophyso-dependent. In the hypophysiary stimulus test, the response of gonadotropins in those old men moves away from the response of hypogonadics considered, by a behaviour much more similar to that of normal adults, even if delayed and prolonged. In all the cases, normal and pathologic, the response of testosterone is variable, perhaps owing to the relation with the various factor which have been noted.
我们对年龄在8岁至95岁的正常男性、原发性和继发性睾丸内分泌障碍患者的两组病例,测定了两种血清促性腺激素和血浆睾酮的分泌值。在该病例的一部分,即正常和原发性性腺功能减退患者中,我们评估了静脉注射促性腺激素释放激素(Gn-RH)后的反应。在已获得的结果中,老年生理性性腺功能减退似乎是一种原发性现象,并非垂体依赖性。在垂体刺激试验中,这些老年男性促性腺激素的反应与所考虑的性腺功能减退患者的反应不同,其行为更类似于正常成年人,尽管延迟且延长。在所有正常和病理情况下,睾酮的反应是可变的,这可能与已注意到的各种因素有关。