Department of Child and Adolescent Psychiatry, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.
Levvel, Academic Center for Child and Adolescent Psychiatry and Specialized Youth Care, Amsterdam, The Netherlands.
BMJ Open. 2022 Jun 28;12(6):e058534. doi: 10.1136/bmjopen-2021-058534.
This paper outlines the study protocol for the Dutch Tackle Your Tics study in youth with tic disorders. Tourette syndrome and chronic tic disorders are prevalent neurodevelopmental disorders, placing considerable burden on youth and their families. Behavioural treatment is the first-line, evidence-based intervention for tic disorders, but tic reduction and availability remain relatively low. Patient associations stress the need for more accessible high-quality treatments, also focusing on improving quality of life. Therefore, the brief, intensive group-based treatment Tackle Your Tics was developed.
Tackle Your Tics is a 4-day intensive and comprehensive group-based intervention for children and adolescents (9-17 years) with Tourette syndrome or a chronic tic disorder. The programme encompasses exposure and response prevention treatment and additional supporting components (coping strategies, relaxation exercises and parent support). To study the effectiveness of Tackle Your Tics and identify predictors/moderators at baseline, a single-blinded randomised controlled trial (n=104) is conducted, comparing Tackle Your Tics (n=52) with a waiting list condition lasting 3 months (n=52). Assessments are performed at similar time points for both groups: at baseline, after 4 weeks, and at 3 and 6 months of follow-up, on tic severity, quality of life and other psychosocial variables.
Ethics approval has been obtained from the medical ethical committee of the Amsterdam Medical Centre (METC nr NL66340.018.18, v3 June 2020). Findings will be presented on national and international conferences, peer-reviewed scientific journals, patient organisation meetings and public media. Patient representatives are fully integrated as part of the research team. If Tackle Your Tics proves to be effective, it can expand evidence-based treatment possibilities for children and adolescents with tic disorders. Identifying the psychosocial predictors/moderators for the effectiveness of this intervention can provide personalised treatment advice in the future.
NL8052.
本文概述了荷兰 Tackle Your Tics 研究在患有抽动障碍的青年中的研究方案。妥瑞氏综合征和慢性抽动障碍是常见的神经发育障碍，给青年及其家庭带来了相当大的负担。行为治疗是抽动障碍的一线、基于证据的干预措施，但抽动减少和可用性仍然相对较低。患者协会强调需要更易获得的高质量治疗方法，同时也注重提高生活质量。因此，开发了简短、密集的基于小组的治疗 Tackle Your Tics。
Tackle Your Tics 是一种为期 4 天的密集且全面的基于小组的干预措施，适用于患有妥瑞氏综合征或慢性抽动障碍的儿童和青少年（9-17 岁）。该方案包括暴露和反应预防治疗以及其他支持性组成部分（应对策略、放松练习和家长支持）。为了研究 Tackle Your Tics 的有效性并在基线时确定预测因素/调节剂，进行了一项单盲随机对照试验（n=104），将 Tackle Your Tics（n=52）与为期 3 个月的等待名单条件（n=52）进行比较。两组在相似的时间点进行评估：基线时、4 周后以及 3 个月和 6 个月的随访时，评估抽动严重程度、生活质量和其他心理社会变量。
阿姆斯特丹医学中心的医学伦理委员会已批准该研究（METC nr NL66340.018.18，v3 年 6 月 2020 年）。研究结果将在全国和国际会议、同行评议的科学期刊、患者组织会议和大众媒体上公布。患者代表作为研究团队的一部分得到了充分的整合。如果 Tackle Your Tics 被证明有效，它可以为患有抽动障碍的儿童和青少年扩大基于证据的治疗选择。确定这种干预措施有效性的心理社会预测因素/调节剂可以为未来提供个性化的治疗建议。
NL8052。
