Ege University Faculty of Medicine, Department of Ophthalmology, İzmir, Turkey.
Turk J Ophthalmol. 2022 Jun 29;52(3):168-173. doi: 10.4274/tjo.galenos.2021.48275.
To compare subfoveal choroidal thickness (SFCT) and choroidal vascular index (CVI) in patients with hyperopic refractive and strabismic amblyopia and healthy subjects.
The study included 17 patients with strabismic amblyopia (Group 1), 29 patients with hyperopic refractive amblyopia (Group 2), and 16 eyes of 16 healthy volunteers (Group 3). Best corrected visual acuity was noted in all patients and volunteers. In addition to detailed anterior and posterior segment examinations, macular images were obtained by enhanced-depth imaging mode of optical coherence tomography (OCT). SFCT measurements were made from these images and CVI was calculated using the Image J program.
No significant difference was found between the groups in terms of age, gender, and intraocular pressure (p=0.27, 0.64, and 0.85, respectively). Mean BCVAs in Group 1 were 0.57±0.16 (0.3-0.8) in the amblyopic eyes, 0.94±0.08 (0.8-1.0) in the fellow eyes, and in Group 2 were 0.61±0.17 (0.2-0.8) in amblyopic eyes, 0.92±0.1 (0.8-1.0) in fellow eyes. BCVA in Group 3 was 1.0±0 (1.0-1.0). Mean SFCT of the amblyopic eyes in Groups 1 and 2 was 341.50±60.4 (277-481) and 370.06±65.3 (247-462), respectively, and in the healthy eyes of Groups 1 and 2 and Group 3 was 321.92±68.26 (251-440), 330.35±74.00 (194-502), and 327.62±40.79 (238-385), respectively. SFCT was significantly greater in the amblyopic eyes of Group 2 compared to Group 3 (p=0.01). Mean CVI was 0.681±0.032 (0.642-0.736) in the amblyopic eyes and 0.685±0.054 (0.587-0.788) in the fellow eyes of Group 1 patients; 0.664±0.033 (0.592-0.719) in the amblyopic eye and 0.707±0.039 (0.625-0.779) in the fellow eye in Group 2 patients; and 0.689±0.031 (0.612-0.748) in Group 3 patients. CVI was significantly lower in the amblyopic eyes of Group 2 compared with fellow eyes (p=0.02) and Group 3 (p=0.025).
Morphological changes may be seen in the choroid in amblyopic eyes. We observed that the choroidal stromal component is increased in hyperopic amblyopic patients especially.
比较远视屈光性和斜视性弱视患者的中心凹下脉络膜厚度（SFCT）和脉络膜血管指数（CVI）。
本研究纳入了 17 名斜视性弱视患者（第 1 组）、29 名远视屈光性弱视患者（第 2 组）和 16 名健康志愿者的 16 只眼（第 3 组）。所有患者和志愿者均记录最佳矫正视力。除了详细的眼前节和眼后节检查外，还通过光学相干断层扫描（OCT）的增强深度成像模式获取黄斑图像。从这些图像中测量 SFCT，并使用 Image J 程序计算 CVI。
第 1 组和第 2 组在年龄、性别和眼内压方面无显著差异（p=0.27、0.64 和 0.85）。第 1 组弱视眼的平均 BCVA 为 0.57±0.16（0.3-0.8），对侧眼为 0.94±0.08（0.8-1.0）；第 2 组弱视眼为 0.61±0.17（0.2-0.8），对侧眼为 0.92±0.1（0.8-1.0）。第 3 组的 BCVA 为 1.0±0（1.0-1.0）。第 1 组和第 2 组弱视眼的平均 SFCT 分别为 341.50±60.4（277-481）和 370.06±65.3（247-462），第 1 组和第 2 组健康眼以及第 3 组的平均 SFCT 分别为 321.92±68.26（251-440）、330.35±74.00（194-502）和 327.62±40.79（238-385）。与第 3 组相比，第 2 组弱视眼的 SFCT 显著更大（p=0.01）。第 1 组患者弱视眼的平均 CVI 为 0.681±0.032（0.642-0.736），对侧眼为 0.685±0.054（0.587-0.788）；第 2 组患者弱视眼为 0.664±0.033（0.592-0.719），对侧眼为 0.707±0.039（0.625-0.779）；第 3 组患者的 CVI 为 0.689±0.031（0.612-0.748）。与对侧眼和第 3 组相比，第 2 组弱视眼的 CVI 明显更低（p=0.02 和 p=0.025）。
在弱视眼中可能会出现脉络膜形态学变化。我们观察到远视性弱视患者的脉络膜基质成分增加。
