Brunori Maurizio, Gianni Stefano
Istituto Pasteur-Fondazione Cenci Bolognetti, Dipartimento di Scienze Biochimiche "A. Rossi Fanelli" and Istituto di Biologia e Patologia Molecolari del CNR, Sapienza Università, Rome, Italy.
Accademia Nazionale dei Lincei, Rome, Italy.
Front Mol Biosci. 2022 Jun 13;9:909567. doi: 10.3389/fmolb.2022.909567. eCollection 2022.
The study of the mechanisms whereby proteins achieve their native functionally competent conformation has been a key issue in molecular biosciences over the last 6 decades. Nevertheless, there are several debated issues and open problems concerning some aspects of this fundamental problem. By considering the emerging complexity of the so-called "native state," we attempt hereby to propose a personal account on some of the key topics in the field, ranging from the relationships between misfolding and diseases to the significance of protein disorder. Finally, we briefly describe the recent and exciting advances in predicting protein structures from their amino acid sequence.
在过去的60年里，蛋白质如何形成其天然功能活性构象的机制研究一直是分子生物科学中的一个关键问题。然而，关于这个基本问题的某些方面，仍存在一些有争议的问题和未解决的难题。通过考虑所谓“天然状态”日益增加的复杂性，我们在此试图就该领域的一些关键主题提出个人观点，内容涵盖从错误折叠与疾病的关系到蛋白质无序的意义。最后，我们简要描述了从氨基酸序列预测蛋白质结构方面最近取得的令人兴奋的进展。
