da Silva Eliclebysson Rodrigo, Rodrigues Menezes Italo Ramon, Brys Ivani
Research Group in Neuroscience and Experimental Psychology, Federal University of Vale do São Francisco, Petrolina, Brazil.
Postgraduate Program in Psychology, Federal University of Vale do São Francisco, Petrolina, Brazil.
J Cent Nerv Syst Dis. 2022 Jun 23;14:11795735221106887. doi: 10.1177/11795735221106887. eCollection 2022.
Transcranial direct current stimulation (tDCS) is one of the most studied non-invasive neuromodulation techniques, presenting itself as a promising technique for several pathologies, such as cognitive decline.
The aim of this study was to conduct a systematic review of the effects of tDCS on the memory of elderly people with mild cognitive impairment or Alzheimer's disease, in order to describe the main protocols used, and to investigate the therapeutic effectiveness of this technique.
869 studies reporting controlled clinical trials were found in the databases PubMed, Web of Science, Lilacs, PsycArticles and Scielo, from which 13 met the expected requirements and were included in the final analysis.
There was a great variability in the stimulation protocols used in the studies; and methodological weaknesses were observed, such as absence of sample size calculation, and of information on effect sizes. Positive effects of tDCS were observed only in five studies, and the combination of stimulation and cognitive training did not seem to potentiate the effects of tDCS.
Although tDCS can be considered a technique with important therapeutic potential, more studies are needed to understand the acute effects of tDCS on memory of elderly people and the durability of these effects over time.
PROSPERO (CRD-42020200573).
经颅直流电刺激（tDCS）是研究最多的非侵入性神经调节技术之一，是一种对认知衰退等多种病症颇具前景的技术。
本研究旨在系统评价tDCS对轻度认知障碍或阿尔茨海默病老年人记忆的影响，描述主要使用的方案，并研究该技术的治疗效果。
在PubMed、科学网、Lilacs、PsycArticles和Scielo数据库中检索到869项报告对照临床试验的研究，其中13项符合预期要求并纳入最终分析。
研究中使用的刺激方案差异很大；观察到方法学上的不足，如未计算样本量以及未提供效应量信息。仅在五项研究中观察到tDCS的积极效果，刺激与认知训练的联合似乎并未增强tDCS的效果。
尽管tDCS可被视为具有重要治疗潜力的技术，但仍需要更多研究来了解tDCS对老年人记忆的急性影响以及这些影响随时间的持续性。
PROSPERO（CRD-42020200573）。
