Kim Jae Young
Department of Life Science, Gachon University, Seongnam, Korea.
Korean J Transplant. 2019 Dec 31;33(4):74-82. doi: 10.4285/jkstn.2019.33.4.74.
Xenotransplantation refers to organ transplantation across species. Immune rejection of xenografts is stronger and faster than that of allografts because of significant molecular differences between species. Recent studies have revealed the involvement of macrophages in xenograft and allograft rejections. Macrophages have been shown to play a critical role in inflammation, coagulation, and phagocytosis in xenograft rejection. This review presents a recent understanding of the role of macrophages in xenograft rejection and possible strategies to control macrophage-mediated xenograft rejection.
异种移植是指跨物种的器官移植。由于物种之间存在显著的分子差异，异种移植物的免疫排斥比同种异体移植更强、更快。最近的研究表明巨噬细胞参与了异种移植和同种异体移植排斥反应。巨噬细胞已被证明在异种移植排斥反应的炎症、凝血和吞噬作用中起关键作用。本文综述了对巨噬细胞在异种移植排斥反应中的作用的最新认识以及控制巨噬细胞介导的异种移植排斥反应的可能策略。
