血浆脑钠肽与血清 HbAlc 联合检测在慢性肺源性心脏病诊断中的临床价值。

The Combination Clinical Value of Plasma Brain Natriuretic Peptide and Serum HbAlc in the Diagnosis of Chronic Pulmonary Heart Disease.

机构信息

Department of Respiratory Medicine, Baoding Fourth Central Hospital, Hebei Province, China.

出版信息

Comput Math Methods Med. 2022 Jun 20;2022:6932179. doi: 10.1155/2022/6932179. eCollection 2022.

DOI:10.1155/2022/6932179

PMID:35770124

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9236788/

Abstract

OBJECTIVE

To analyze the combination clinical value of plasma brain natriuretic peptide and serum glycated hemoglobin (HbAlc) in chronic pulmonary heart disease.

METHODS

A total of 200 patients with chronic pulmonary heart disease admitted to our hospital from January 2021 to January 2022 were selected as the observation group, and 200 healthy subjects were selected as the control group during the same period. All subjects were examined by an ECG vector map and plasma BNP, and HbAlc levels were detected to analyze the value and clinical significance of each index in single diagnosis and combined diagnosis.

RESULTS

Plasma BNP and HbAlc levels in the observation group were significantly higher than those in the control group ( < 0.05). There were 154 BNP positive, 146 HbAlc positive, 164 parallel combined diagnosis positive, and 132 serial combined diagnosis positive. Sensitivity of series combination diagnosis was significantly higher than other indexes ( < 0.05); especially, parallel combination diagnosis was significantly higher than other indexes ( < 0.05). Besides, area under the ROC curve of parallel combination diagnosis and series combination diagnosis was significantly higher than that of each index alone diagnosis ( < 0.05).

CONCLUSION

In the diagnosis of chronic pulmonary heart disease, the combination of plasma BNP and HbAlc can effectively improve the diagnostic specificity and sensitivity, as well as improve the area under the ROC curve.

摘要

目的

分析血浆脑钠肽与血清糖化血红蛋白（HbAlc）联合在慢性肺源性心脏病中的临床价值。

方法

选取我院 2021 年 1 月至 2022 年 1 月收治的 200 例慢性肺源性心脏病患者作为观察组，同期选取 200 例健康体检者作为对照组。对所有对象均进行心电图向量图检查和血浆 BNP、HbAlc 水平检测，分析各指标单项诊断及联合诊断的价值及临床意义。

结果

观察组血浆 BNP、HbAlc 水平均明显高于对照组（ < 0.05）。BNP 阳性 154 例，HbAlc 阳性 146 例，平行联合诊断阳性 164 例，串行联合诊断阳性 132 例。串行联合诊断的灵敏度明显高于其他指标（ < 0.05）；尤其平行联合诊断灵敏度明显高于其他指标（ < 0.05）。此外，平行联合诊断和串行联合诊断的 ROC 曲线下面积均明显高于各单项诊断（ < 0.05）。