Intensive Care Unit, Daqing Oilfield General Hospital, Daqing, Heilongjiang Province, China.
Eur Rev Med Pharmacol Sci. 2017 Sep;21(18):4181-4185.
To investigate the correlation between the levels of urine calcium integrin binding protein-1 (CIB1) and serum precursor N-terminal brain natriuretic peptide (pro-BNP) and ischemic heart failure.
30 patients diagnosed as acute ischemic heart failure for the first time in our hospital from January to August 2016 were continuously selected as the observation group 1, 30 patients with chronic stable ischemic heart failure as the observation group 2, and 30 healthy volunteers as the control group. Urine CIB1 level was detected via enzyme linked immunosorbent assay (ELISA) and serum pro-BNP level was detected via radioimmunoassay. The linear correlation between the CIB1 and pro-BNP levels in observation group 1 was observed, and the diagnostic value of CIB1 and pro-BNP levels for chronic stable ischemic heart failure were analyzed using the receiver operating characteristic (ROC) curve.
CIB1 and pro-BNP levels in the observation group 1 were significantly higher than those in the observation group 2. These levels were significantly lower in the control group (p < 0.05). In the observation group 1, CIB1 and pro-BNP levels were positively correlated (p < 0.05). The diagnostic accuracy of CIB1 for chronic stable ischemic heart failure in the observation group 2 (area under the curve, AUC) was 0.854, the sensitivity was 86.6% and the specificity was 82.5%, respectively. The diagnostic accuracy of pro-BNP was 0.823, the sensitivity was 83.5% and the specificity was 85.9%, respectively.
There is a significant correlation between the urine CIB1 and serum pro-BNP levels in patients with acute ischemic heart failure. In patients with chronic stable ischemic heart failure, the diagnostic value of urine CIB1 outperforms that of serum pro-BNP, which still needs further study.
探讨尿钙整合素结合蛋白-1（CIB1）水平与血清前体 N 末端脑钠肽（pro-BNP）与缺血性心力衰竭的相关性。
连续选取我院 2016 年 1 月至 8 月首次诊断为急性缺血性心力衰竭的 30 例患者为观察组 1，30 例慢性稳定型缺血性心力衰竭患者为观察组 2，30 例健康志愿者为对照组。采用酶联免疫吸附法（ELISA）检测尿 CIB1 水平，放射免疫法检测血清 pro-BNP 水平。观察观察组 1 中 CIB1 与 pro-BNP 水平的线性相关性，并采用受试者工作特征（ROC）曲线分析 CIB1 和 pro-BNP 水平对慢性稳定型缺血性心力衰竭的诊断价值。
观察组 1 的 CIB1 和 pro-BNP 水平明显高于观察组 2，明显低于对照组（p < 0.05）。观察组 1 中 CIB1 与 pro-BNP 水平呈正相关（p < 0.05）。观察组 2 中 CIB1 对慢性稳定型缺血性心力衰竭的诊断准确性（曲线下面积，AUC）为 0.854，灵敏度为 86.6%，特异性为 82.5%。pro-BNP 的诊断准确性为 0.823，灵敏度为 83.5%，特异性为 85.9%。
急性缺血性心力衰竭患者尿 CIB1 与血清 pro-BNP 水平呈显著正相关。在慢性稳定型缺血性心力衰竭患者中，尿 CIB1 的诊断价值优于血清 pro-BNP，仍需进一步研究。
