Yu Zhongjie, Wang Jing, Nan Fulong, Shi Wenyi, Zhang Xianjuan, Jiang Shasha, Wang Bin
Department of Special Medicine, School of Basic Medicine, Qingdao Medical College, Qingdao University, Qingdao, China.
Oral Research Center, Qingdao Municipal Hospital, Qingdao, China.
Front Microbiol. 2022 Jun 13;13:918213. doi: 10.3389/fmicb.2022.918213. eCollection 2022.
Human cytomegalovirus (HCMV) is a β-herpesvirus whose genome consists of double stranded linear DNA. HCMV genome can generate non-coding RNAs (ncRNAs) through transcription in its host cells. Besides that, HCMV infection also changes the ncRNAs expression profile of the host cells. ncRNAs play a key role in maintaining the normal physiological activity of cells, and the disorder of ncRNAs expression has numerous adverse effects on cells. However, until now, the relationship between ncRNAs and HCMV-induced adverse effects are not summarized in detail. This review aims to give a systematic summary of the role of HCMV infection in ncRNAs expression while providing insights into the molecular mechanism of unnormal cellular events caused by ncRNAs disorder. ncRNAs disorder induced by HCMV infection is highly associated with cell proliferation, apoptosis, tumorigenesis, and immune regulation, as well as the development of cardiovascular diseases, and the potential role of biomarker. We summarize the studies on HCMV associated ncRNAs disorder and suggest innovative strategies for eliminating the adverse effects caused by HCMV infection.
人巨细胞病毒（HCMV）是一种β疱疹病毒，其基因组由双链线性DNA组成。HCMV基因组可通过在宿主细胞中的转录产生非编码RNA（ncRNA）。除此之外，HCMV感染还会改变宿主细胞的ncRNA表达谱。ncRNA在维持细胞正常生理活动中起关键作用，ncRNA表达紊乱对细胞有诸多不利影响。然而，迄今为止，ncRNA与HCMV诱导的不利影响之间的关系尚未得到详细总结。本综述旨在系统总结HCMV感染在ncRNA表达中的作用，同时深入探讨由ncRNA紊乱引起的异常细胞事件的分子机制。HCMV感染诱导的ncRNA紊乱与细胞增殖、凋亡、肿瘤发生、免疫调节以及心血管疾病的发展高度相关，以及生物标志物的潜在作用。我们总结了关于HCMV相关ncRNA紊乱的研究，并提出消除HCMV感染引起的不利影响的创新策略。
