Zeng Haobin, Li Likang, Zhang Bo, Xu Xu, Li Guowei, Chen Maoshui
Department of Orthopedics No. 2 (Spinal Surgery), Guangdong Provincial Hospital of Chinese Medicine, Zhuhai, China.
Center for Clinical Epidemiology and Methodology (CCEM), Guangdong Second Provincial General Hospital, Guangzhou, China.
Ther Adv Endocrinol Metab. 2022 Jun 24;13:20420188221106884. doi: 10.1177/20420188221106884. eCollection 2022.
Evidence investigating sleep pattern in relation to bone health in elderly participants with osteoporosis remains sparse. We aimed to assess the relationship between sleep pattern incorporating five sleep characteristics (snoring, midnight waking up, insomnia, sleep duration, and daytime napping) and bone mineral density (BMD) in elderly participants with osteoporotic fracture.
A cross-sectional study was conducted to include eligible elderly patients from the Department of Orthopedics who were admitted to hospital due to an osteoporotic fracture. Sleep pattern was constructed based on total sleep scores and categorized into healthy, intermediate, and poor pattern groups. Multivariable logistic regression model was used to assess sleep pattern in relation to risk of low BMD.
A total of 169 elderly patients with osteoporotic fracture were included in this study (mean age: 71.91 years; 87.57% females). There were 36 (21.30%), 107 (63.31%), and 26 (15.38%) patients with healthy, intermediate, and poor sleep pattern, respectively. Compared with healthy sleep pattern, no significant relationship between intermediate sleep pattern and BMD was detected [odds ratio (OR) = 1.72, 95% confidence interval (CI): 0.74, 3.97, = 0.21), while poor pattern was significantly associated with decreased BMD (OR = 3.50, 95% CI: 1.10, 11.14, = 0.034).
The majority of elderly patients with osteoporotic fracture had unhealthy sleep pattern; poor sleep pattern was significantly related to reduced BMD when compared with healthy pattern. Further high-quality evidence is needed to assess and validate the relationship between sleep pattern and risk of low BMD in the elderly.
关于骨质疏松症老年参与者睡眠模式与骨骼健康关系的研究证据仍然稀少。我们旨在评估包含五种睡眠特征（打鼾、半夜醒来、失眠、睡眠时间和日间小睡）的睡眠模式与骨质疏松性骨折老年参与者骨密度（BMD）之间的关系。
进行了一项横断面研究，纳入了骨科因骨质疏松性骨折入院的符合条件的老年患者。根据总睡眠得分构建睡眠模式，并分为健康、中等和不良模式组。使用多变量逻辑回归模型评估睡眠模式与低骨密度风险的关系。
本研究共纳入169例骨质疏松性骨折老年患者（平均年龄：71.91岁；87.57%为女性）。分别有36例（21.30%）、107例（63.31%）和26例（15.38%）患者具有健康、中等和不良睡眠模式。与健康睡眠模式相比，未检测到中等睡眠模式与骨密度之间存在显著关系[比值比（OR）=1.72，95%置信区间（CI）：0.74，3.97，P=0.21]，而不良模式与骨密度降低显著相关（OR=3.50，95%CI：1.10，11.14，P=0.034）。
大多数骨质疏松性骨折老年患者睡眠模式不健康；与健康模式相比，不良睡眠模式与骨密度降低显著相关。需要进一步的高质量证据来评估和验证睡眠模式与老年人低骨密度风险之间的关系。
