Division of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, 10400, Thailand.
Division of Endocrinology, Diabetes and Metabolism, University of Illinois at Chicago, Chicago, IL, USA.
Sci Rep. 2018 Jul 3;8(1):10016. doi: 10.1038/s41598-018-28260-w.
Low bone mass is more prevalent with increasing age. Studies have found associations between sleep duration, sleep quality and obstructive sleep apnea and bone mineral density (BMD). However, less is known about the relationship between daytime napping and BMD. We aimed to investigate the association between daytime napping and BMD in elderly Thai women. Demographic data, lifestyle information and sleep characteristics were obtained by interviewing 387 elderly women. Weight and height were measured. Serum 25-hydroxyvitamin D [25(OH)D] was measured by radioimmunoassay. BMD was measured by dual-energy X-ray absorptiometry (DXA). Higher BMI and having type 2 diabetes (T2DM) were correlated with higher lumbar spine 2-4 (L2-4) BMD, while younger age, higher BMI and higher serum 25(OH)D level were correlated with higher femoral neck (FN) and total hip (TH) BMD. After adjusting for age, age at menopause, BMI, 25(OH)D level and T2DM, a higher frequency of weekly daytime napping was associated with lower FN and TH BMD but not at L2-4 BMD. Additionally, longer daytime napping duration was negatively associated with BMD at TH. In summary higher frequency and longer duration of daytime napping are associated with lower femoral BMD in elderly women. Mechanisms underlying these associations should be further explored.
骨量减少随着年龄的增长而更为普遍。研究发现，睡眠时间、睡眠质量与阻塞性睡眠呼吸暂停和骨矿物质密度（BMD）之间存在关联。然而，日间小睡与 BMD 之间的关系则知之甚少。我们旨在调查日间小睡与老年泰国女性 BMD 之间的关系。通过访谈 387 名老年女性获得人口统计学数据、生活方式信息和睡眠特征。测量体重和身高。通过放射免疫测定法测量血清 25-羟维生素 D [25(OH)D]。通过双能 X 射线吸收法（DXA）测量 BMD。更高的 BMI 和患有 2 型糖尿病（T2DM）与更高的腰椎 2-4（L2-4）BMD 相关，而年龄较小、更高的 BMI 和更高的血清 25(OH)D 水平与更高的股骨颈（FN）和全髋（TH）BMD 相关。在调整年龄、绝经年龄、BMI、25(OH)D 水平和 T2DM 后，每周日间小睡频率更高与 FN 和 TH BMD 降低相关，但与 L2-4 BMD 无关。此外，日间小睡时间延长与 TH 处的 BMD 呈负相关。综上所述，较高的日间小睡频率和较长的日间小睡持续时间与老年女性的股骨 BMD 降低相关。应进一步探讨这些关联的潜在机制。
