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在南非女性围孕期和孕期中，影响 PrEP 接种和坚持使用的因素：定性分析。

Influences on PrEP Uptake and Adherence Among South African Women During Periconception and Pregnancy: A Qualitative Analysis.

机构信息

Department of Global Health & Social Medicine, Harvard Medical School, 641 Huntington Ave, Boston, USA.

Harvard Global, Cambridge, MA, USA.

出版信息

AIDS Behav. 2023 Jan;27(1):208-217. doi: 10.1007/s10461-022-03757-8. Epub 2022 Jun 30.

DOI:10.1007/s10461-022-03757-8
PMID:35771311
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9245881/
Abstract

Pre-exposure prophylaxis (PrEP) is highly effective for HIV prevention, yet PrEP delivery to women in periconception and pregnancy has lagged. We report qualitative research from a study evaluating PrEP use as part of safer conception care for 330 South African women. Fifty-two semi-structured interviews were conducted with 25 study participants to identify influences on PrEP adherence. Influences were: (1) changing proximity to male partners; (2) COVID-19 lockdown; (3) mobile lifestyle; (4) PrEP-related stigma; (5) disclosure of PrEP use; and (6) pregnancy and motherhood. Data also revealed important contextual information shaping adherence influences for women, including: (a) not living with partners, (b) partners as drivers of pregnancy intention, and (c) feeling at high risk for HIV. Disclosure of PrEP use, addressing stigma, strategies for traveling with pills, and counseling on prevention effective adherence are promising components of PrEP-inclusive HIV prevention interventions for South African women who are pregnant or planning pregnancy.

摘要

暴露前预防（PrEP）在预防 HIV 方面非常有效，但在围孕期和孕期向妇女提供 PrEP 的工作却滞后了。我们报告了一项评估 PrEP 作为更安全妊娠护理一部分的使用情况的研究的定性研究结果，该研究纳入了 330 名南非妇女。对 25 名研究参与者进行了 52 次半结构化访谈，以确定影响 PrEP 依从性的因素。这些影响因素包括：（1）与男性伴侣的距离变化；（2）COVID-19 封锁；（3）流动生活方式；（4）与 PrEP 相关的耻辱感；（5）PrEP 使用的披露；以及（6）怀孕和母亲身份。数据还揭示了影响妇女坚持 PrEP 的重要背景信息，包括：（a）不与伴侣同住；（b）伴侣是怀孕意愿的驱动因素；（c）感到 HIV 感染风险高。PrEP 使用的披露、解决耻辱感、携带药物旅行的策略以及预防有效依从性的咨询，是为南非怀孕或计划怀孕的妇女提供包含 PrEP 的 HIV 预防干预措施的有希望的组成部分。

相似文献

[1]
Influences on PrEP Uptake and Adherence Among South African Women During Periconception and Pregnancy: A Qualitative Analysis.

AIDS Behav. 2023-1

[2]
Protocol for a longitudinal study to evaluate the use of tenofovir-based PrEP for safer conception and pregnancy among women in South Africa.

BMJ Open. 2019-7-26

[3]
Oral preexposure prophylaxis uptake, adherence, and persistence during periconception periods among women in South Africa.

AIDS. 2024-7-15

[4]
A qualitative exploration to understand barriers and facilitators to daily oral PrEP uptake and sustained adherence among HIV-negative women planning for or with pregnancy in rural Southwestern Uganda.

J Int AIDS Soc. 2022-3

[5]
The influence of HIV-related stigma on PrEP disclosure and adherence among adolescent girls and young women in HPTN 082: a qualitative study.

J Int AIDS Soc. 2020-3

[6]
"I had Made the Decision, and No One was Going to Stop Me" -Facilitators of PrEP Adherence During Pregnancy and Postpartum in Cape Town, South Africa.

AIDS Behav. 2021-12

[7]
Barriers to Oral HIV Pre-exposure Prophylaxis (PrEP) Adherence Among Pregnant and Post-partum Women from Cape Town, South Africa.

AIDS Behav. 2022-9

[8]
Maternal PrEP Use in HIV-Uninfected Pregnant Women in South Africa: Role of Stigma in PrEP Initiation, Retention and Adherence.

AIDS Behav. 2022-1

[9]
Recent Alcohol Use Is Associated With Increased Pre-exposure Prophylaxis (PrEP) Continuation and Adherence Among Pregnant and Postpartum Women in South Africa.

J Acquir Immune Defic Syndr. 2023-3-1

[10]
Perceptions of HIV Preexposure Prophylaxis Among Young Pregnant Women from Rural KwaZulu-Natal, South Africa.

AIDS Patient Care STDS. 2019-5

引用本文的文献

[1]
Delivery models of HIV pre-exposure prophylaxis and their influence on uptake in South Africa: An integrative review.

South Afr J HIV Med. 2025-4-17

[2]
PrEP Uptake and Utilisation Among Adolescent Girls and Young Women in Sub-Saharan Africa: A Scoping Review.

AIDS Behav. 2025-6

[3]
PrEP Awareness and Coverage: Results from the 2022 South Africa Antenatal HIV Sentinel Survey.

AIDS Behav. 2025-5

[4]
A qualitative exploration of sexually transmitted infection (STI) partner notification preferences and practices among women planning for pregnancy and offered HIV pre-exposure prophylaxis in Durban, South Africa.

BMC Public Health. 2025-2-11

[5]
Understanding the cost-utility of implementing HIV self-testing with digital-based supports.

Front Public Health. 2025-1-14

[6]
Integration of HIV pre-exposure prophylaxis (PrEP) services for pregnant and breastfeeding women in eight primary care clinics: results of an implementation science study.

BMC Glob Public Health. 2024-8-26

[7]
The impact of the COVID-19 pandemic on HIV healthcare delivery for females in sub-Saharan Africa: A scoping review.

PLOS Glob Public Health. 2024-12-5

[8]
Health System Factors Influencing the Integration of Pre-Exposure Prophylaxis into Antenatal and Postnatal Clinic Services in Cape Town, South Africa.

Glob Health Sci Pract. 2024-12-20

[9]
Barriers and facilitators to uptake and use of oral pre-exposure prophylaxis in pregnant and postpartum women: a qualitative meta-synthesis.

BMC Public Health. 2024-6-20

[10]
Oral preexposure prophylaxis uptake, adherence, and persistence during periconception periods among women in South Africa.

AIDS. 2024-7-15

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