1-[4-(4-Chlorophenyl)-2-(2,6-dichlorophenylthio)-n-butyl]-1H-imidazole nitrate, a new potent antifungal agent.
作者信息
Walker K A, Braemer A C, Hitt S, Jones R E, Matthews T R
出版信息
J Med Chem. 1978 Aug;21(8):840-3. doi: 10.1021/jm00206a028.
PMID:357722
Abstract
The preparation and antifungal properties of 1-[4-(4-chlorophenyl)-2-(2,6-dichlorophenylthio)-n-butyl]-1H-imidazole nitrate 1 are described. It is particularly effective against in vivo Candida albicans infections (mice), maintaining good activity down to 0.25% formulation strength and showing unusually low reinfection rates after treatment is ended.
摘要
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