College of Chemistry, Fuzhou University, Fuzhou 350116, Fujian, China.
Division of Hemostasis & Thrombosis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston MA02215, United States.
Pharmacol Res. 2022 Aug;182:106331. doi: 10.1016/j.phrs.2022.106331. Epub 2022 Jun 27.
The Angiopoietin (Ang)-Tyrosine kinase with immunoglobulin-like and EGF-like domains (Tie) axis is an endothelial cell-specific ligand-receptor signaling pathway necessary for vascular and lymphatic development. The Ang-Tie axis is involved in regulating angiogenesis, vascular remodeling, vascular permeability, and inflammation to maintain vascular quiescence. Disruptions in the Ang-Tie axis are involved in many vascular and lymphatic diseases and play an important role in physiological and pathological vascular processes. Given recent advances in the Ang-Tie axis in the vascular and lymphatic systems, this review focuses on the multiple functions of the Ang-Tie axis in inflammation-induced vascular permeability, vascular remodeling, atherosclerosis, ocular angiogenesis, tumor angiogenesis, and metastasis. A summary of relevant therapeutic approaches to the Ang-Tie axis, including therapeutic antibodies, recombinant proteins and small molecule drugs are also discussed. The purpose of this review is to provide new hypotheses and identify potential therapeutic strategies based on the Ang-Tie signaling axis for the treatment of vascular and lymphatic-related diseases.
血管生成素（Ang）-含免疫球蛋白样和表皮生长因子样结构域的酪氨酸激酶（Tie）轴是一种内皮细胞特异性配体-受体信号通路，对于血管和淋巴管的发育是必需的。Ang-Tie 轴参与调节血管生成、血管重塑、血管通透性和炎症，以维持血管的静止状态。Ang-Tie 轴的破坏与许多血管和淋巴管疾病有关，并在生理和病理血管过程中发挥重要作用。鉴于 Ang-Tie 轴在血管和淋巴管系统中的最新进展，本综述重点关注 Ang-Tie 轴在炎症诱导的血管通透性、血管重塑、动脉粥样硬化、眼部血管生成、肿瘤血管生成和转移中的多种功能。还讨论了与 Ang-Tie 轴相关的治疗方法的总结，包括治疗性抗体、重组蛋白和小分子药物。本综述的目的是基于 Ang-Tie 信号通路提供新的假说并确定潜在的治疗策略，以治疗与血管和淋巴管相关的疾病。
