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本文引用的文献

1
Preoperative epidural steroid injections are not associated with increased rates of infection and dural tear in lumbar spine surgery.术前硬膜外类固醇注射与腰椎手术感染率和硬膜撕裂率增加无关。
Eur Spine J. 2021 Apr;30(4):870-877. doi: 10.1007/s00586-020-06566-6. Epub 2020 Aug 13.
2
The Effects of Steroids on Survival of Mouse and Human Tympanic Membrane Fibroblasts.类固醇对小鼠和人鼓膜成纤维细胞生存的影响。
Otolaryngol Head Neck Surg. 2020 Aug;163(2):382-388. doi: 10.1177/0194599820912739. Epub 2020 Mar 24.
3
Recent Preoperative Lumbar Epidural Steroid Injection Is an Independent Risk Factor for Incidental Durotomy During Lumbar Discectomy.近期术前腰椎硬膜外类固醇注射是腰椎间盘切除术中意外硬脊膜切开的独立危险因素。
Global Spine J. 2019 Dec;9(8):807-812. doi: 10.1177/2192568219833656. Epub 2019 Mar 21.
4
An epidural steroid injection in the 6 months preceding a lumbar decompression without fusion predisposes patients to post-operative infections.在进行非融合性腰椎减压手术前6个月内进行硬膜外类固醇注射会使患者更容易发生术后感染。
J Spine Surg. 2018 Sep;4(3):529-533. doi: 10.21037/jss.2018.09.05.
5
Comparison of Clinical Efficacy of Epidural Injection With or Without Steroid in Lumbosacral Disc Herniation: A Systematic Review and Meta-analysis.硬膜外注射与不注射类固醇治疗腰椎间盘突出症的临床疗效比较:系统评价和荟萃分析。
Pain Physician. 2018 Sep;21(5):449-468.
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7
Lumbar epidural steroid injections for herniation and stenosis: incidence and risk factors of subsequent surgery.腰椎硬膜外类固醇注射治疗突出和狭窄:后续手术的发生率和危险因素。
Spine J. 2019 Feb;19(2):199-205. doi: 10.1016/j.spinee.2018.05.034. Epub 2018 Jun 26.
8
Intraoperative Results and Postoperative Clinical Outcomes of Lumbar Microdiscectomy in Patients who Previously Received a Transforaminal Anterior Epidural Steroid Injection for Lumbar Radiculopathy.曾接受经椎间孔前路硬膜外类固醇注射治疗腰椎神经根病的患者行腰椎显微椎间盘切除术的术中结果及术后临床疗效
Turk Neurosurg. 2018;28(2):263-269. doi: 10.5137/1019-5149.JTN.19209-16.1.
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Mayo Clin Proc. 2017 Jan;92(1):88-97. doi: 10.1016/j.mayocp.2016.06.030. Epub 2016 Nov 9.
10
Is There an Association of Epidural Corticosteroid Injection With Postoperative Surgical Site Infection After Surgery for Lumbar Degenerative Spine Disease?腰椎退行性疾病手术后,硬膜外注射皮质类固醇与术后手术部位感染之间是否存在关联?
Spine (Phila Pa 1976). 2016 Oct 1;41(19):1542-1547. doi: 10.1097/BRS.0000000000001548.

术前腰椎硬膜外类固醇注射增加了微创腰椎间盘切除术中硬脊膜撕裂的风险。

Preoperative Lumbar Epidural Steroid Injection Increases the Risk of a Dural Tear During Minimally Invasive Lumbar Discectomy.

作者信息

Shakya Akash, Sharma Ayush, Singh Vijay, Rathore Amisha, Garje Vinayak, Wadgave Venkatramana, Kakadiya Ghanshyam, Marathe Nandan

机构信息

Department of Orthopaedics and Spine Surgery, Dr BAM Hospital, Mumbai, India

Department of Orthopaedics and Spine Surgery, Dr BAM Hospital, Mumbai, India.

出版信息

Int J Spine Surg. 2022 Jun;16(3):505-511. doi: 10.14444/8249.

DOI:10.14444/8249
PMID:35772973
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9650179/
Abstract

BACKGROUND

Preoperative lumbar epidural steroid injections (LESI) are known to be a risk factor for intraoperative dural tears in traditional spine surgery. However, whether the same holds true after minimally invasive surgery is debatable. The authors decided to investigate the incidence of complications in patients undergoing minimally invasive lumbar discectomy after a preoperative LESI.

METHODS

A retrospective analysis was carried out on patients ages 21 to 65 years who underwent minimally invasive lumbar discectomy over 3 years between November 2017 and October 2020. These were classified into 2 groups based on the administration of an LESI within a year of surgery. Those receiving LESI were further subdivided on the basis of the proximity of the injection to the surgery. The complications encountered during and up to 6 months after the surgery were recorded. Various demographic variables were also noted.

RESULTS

A total of 315 patients were included in the study, of which 129 were in the LESI group and 186 were in the non-LESI group. The overall complication rate was 13.65%, with 17.83% in the LESI group and 10.75% in the non-LESI group ( = 0.07). Patients receiving an LESI were 2.49 times more likely to suffer from intraoperative dural tears compared to the other group (95% CI: 1.00-6.20, = 0.049). This was more prevalent in those who were administered an LESI within 3 months of the surgery (OR: 3.24, 95% CI: 1.12-9.40, = 0.03). However, the rates of other complications including infections were comparable.

CONCLUSIONS

A history of LESI within 3 months of the surgery is a risk factor of intraoperative dural tears. However, other complications, including infections, are not affected by a preoperative LESI.

CLINICAL RELEVANCE

A history of an LESI within 3 months of a proposed minimally invasive discectomy should make the surgeon extra-cautious of the risk of a dural tear.

摘要

背景

术前腰椎硬膜外类固醇注射(LESI)已知是传统脊柱手术中术中硬脊膜撕裂的一个危险因素。然而,在微创手术后情况是否相同仍存在争议。作者决定调查术前接受LESI的患者在接受微创腰椎间盘切除术后的并发症发生率。

方法

对2017年11月至2020年10月期间3年内接受微创腰椎间盘切除术的21至65岁患者进行回顾性分析。根据手术一年内是否接受LESI将这些患者分为两组。接受LESI的患者进一步根据注射与手术的接近程度进行细分。记录手术期间及术后6个月内遇到的并发症。还记录了各种人口统计学变量。

结果

该研究共纳入315例患者,其中LESI组129例,非LESI组186例。总体并发症发生率为13.65%,LESI组为17.83%,非LESI组为10.75%(P = 0.07)。与另一组相比,接受LESI的患者术中硬脊膜撕裂的可能性高2.49倍(95%可信区间:1.00 - 6.20,P = 0.049)。这在手术3个月内接受LESI的患者中更为普遍(比值比:3.24,95%可信区间:1.12 - 9.40,P = 0.03)。然而,包括感染在内的其他并发症发生率相当。

结论

手术3个月内有LESI史是术中硬脊膜撕裂的一个危险因素。然而,包括感染在内的其他并发症不受术前LESI的影响。

临床意义

拟行微创椎间盘切除术3个月内有LESI史应使外科医生格外警惕硬脊膜撕裂的风险。