Monzote Lianet, González Daniel, Blanco Orestes, Fraga Jorge, Capó Virginia, Herrera Alberto, Montalvo Ana Margarita
Parasitology Department, Instituto de Medicina Tropical Pedro Kourí, Autopista Novia del Mediodía Km 6 1/2, La Habana, Cuba.
Department of Medicine, Instituto de Medicina Tropical Pedro Kourí, Autopista Novia del Mediodía Km 6 1/2, La Habana, Cuba.
Trop Dis Travel Med Vaccines. 2022 Jul 1;8(1):15. doi: 10.1186/s40794-022-00171-9.
Leishmaniasis is a vector-borne disease caused by several species from genus Leishmania. An increase in the number of cases related to human movement has been informed in the last years. Due to the increase of suspicious leishmaniasis cases arriving in Cuba during 2017, a general analysis is presented herein.
Clinical samples were collected from 5 patients suspicious of leishmaniasis, received from January to December 2017 at the Institute of Tropical Medicine Pedro Kourí, Cuba. Skin lesion samples were analyzed using different diagnostic assays: direct smear, histological examination, and molecular analysis for species identification. Epidemiological and demographic data were requested from each case and analyzed. Treatment and follow up of patient was also performed.
Five cases were confirmed as Leishmania infection according to microscopic observation and molecular methods results. PCR-18S, PCR-N/RFLP and PCR-F/RFLP identified the following species: L. panamensis (2 cases), L. braziliensis (1 case), L.panamensis/L.guyanensis (1 case), L. mexicana complex (1 case). In treated patients, drugs were well tolerated, cure were documented and no relapse have been currently reported (3 years later).
Clinical characteristics, demographic data, and epidemiological features of infection for each case evidence the potential risk related with travel to endemic areas of leishmaniasis.
Cutaneous leishmaniasis, Epidemiology, Imported cases.
利什曼病是一种由利什曼原虫属的几种物种引起的媒介传播疾病。近年来，与人类流动相关的病例数量有所增加。由于2017年抵达古巴的疑似利什曼病病例增多，本文进行了综合分析。
从2017年1月至12月在古巴佩德罗·库里热带医学研究所接收的5例疑似利什曼病患者中采集临床样本。对皮肤病变样本采用不同的诊断方法进行分析：直接涂片、组织学检查以及用于物种鉴定的分子分析。收集并分析了每个病例的流行病学和人口统计学数据。同时对患者进行了治疗和随访。
根据显微镜观察和分子方法结果，5例确诊为利什曼原虫感染。PCR-18S、PCR-N/RFLP和PCR-F/RFLP鉴定出以下物种：巴拿马利什曼原虫（2例）、巴西利什曼原虫（1例）、巴拿马利什曼原虫/圭亚那利什曼原虫（1例）、墨西哥利什曼原虫复合体（1例）。在接受治疗的患者中，药物耐受性良好，有治愈记录，目前尚未报告复发情况（3年后）。
每个病例的临床特征、人口统计学数据和感染的流行病学特征证明了前往利什曼病流行地区旅行存在的潜在风险。
皮肤利什曼病；流行病学；输入性病例
