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[尾状核GABA能结构刺激对氟哌啶醇作用发展影响的脑电图分析]

[EEG analysis of the effect of stimulation of GABAergic structures of the caudate nucleus on the development of the effect of haloperidol].

作者信息

Shugalev N P, Shiriaev A D

出版信息

Zh Vyssh Nerv Deiat Im I P Pavlova. 1987 Jan-Feb;37(1):128-34.

PMID:3577401
Abstract

Functional significance of GABA-structures of the caudate nucleus was studied by EEG analysis of the influence of stimulation of these structures on the development of the effect of systemic introduction of the blockader of dopaminergic receptors haloperidol. Microinjections of GABA to the caudate nucleus prevented the suppressing action of haloperidol on food-procuring cats behaviour and led to restoration of the EEG-reaction to conditioned sound stimuli. A conclusion is made about an important role of GABA-ergic structures in the mechanisms of dopaminergic control of the inhibitory function of the caudate nucleus.

摘要

通过脑电图分析尾状核GABA结构对多巴胺能受体阻滞剂氟哌啶醇全身给药效果发展的影响,研究了尾状核GABA结构的功能意义。向尾状核微量注射GABA可防止氟哌啶醇对获取食物的猫行为的抑制作用,并导致对条件性声音刺激的脑电图反应恢复。得出结论,GABA能结构在多巴胺能控制尾状核抑制功能的机制中起重要作用。

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