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[尾状核头部含脑啡肽系统与含多巴胺系统在犬条件性食物反射形成中的相互作用]

[Interaction of the enkephalin- and dopamine-containing systems of the caudate nucleus head in realizing a conditioned food reflex in dogs].

作者信息

Suvorov N F, Iakimovskiĭ A F

出版信息

Fiziol Zh SSSR Im I M Sechenova. 1984 Feb;70(2):113-7.

PMID:6370737
Abstract

Bilateral microinjections of 15 and 45 mg of Ley-enkephalin synthetic analogue D-Ala2-D-Leu enkephalin-Arg6 into the head of caudate nuclei in dogs enhanced parameters of Pavlovian alimentary conditioned reflexes and improved the differential inhibition. Microinjection of 60 mg dopamine exerted opposite effects. The opiate antagonist naloxone (0.8 mg) prevented the effects of both enkephalin and dopamine whereas a microinjection of dopamine-receptors blocking agent haloperidol (10 mg) prevented only the dopamine effects. The data suggest enkephalin-dopamine functional interaction to occur in neostriatal area in alimentary conditioning behaviour.

摘要

向犬的尾状核头部双侧微量注射15毫克和45毫克亮氨酸脑啡肽合成类似物D-丙氨酸2-D-亮氨酸脑啡肽-精氨酸6，可增强巴甫洛夫食物性条件反射的参数，并改善分化抑制。注射60毫克多巴胺则产生相反的效果。阿片拮抗剂纳洛酮（0.8毫克）可阻断脑啡肽和多巴胺的作用，而微量注射多巴胺受体阻断剂氟哌啶醇（10毫克）仅能阻断多巴胺的作用。这些数据表明，在食物性条件反射行为中，脑啡肽与多巴胺在新纹状体区域存在功能相互作用。

相似文献

1
[Interaction of the enkephalin- and dopamine-containing systems of the caudate nucleus head in realizing a conditioned food reflex in dogs].[尾状核头部含脑啡肽系统与含多巴胺系统在犬条件性食物反射形成中的相互作用]
Fiziol Zh SSSR Im I M Sechenova. 1984 Feb;70(2):113-7.
2
[Role of enkephalin-reactive system of the caudate nucleus in acquisition of alimentary conditioned reflex in dogs].[尾状核脑啡肽反应系统在犬获得性条件性食物反射中的作用]
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[The effect of the chronic injection of leu-enkephalin and its tetrapeptide analog into the canine caudate nucleus on the realization of conditioned food reflexes].[向犬尾状核慢性注射亮氨酸脑啡肽及其四肽类似物对条件性食物反射实现的影响]
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[A comparison of the effects of single and chronic microinjections of GABA and picrotoxin into the caudate nucleus on the conditioned reflexes of dogs].[单次及慢性向犬尾状核微量注射γ-氨基丁酸（GABA）和印防己毒素对犬条件反射影响的比较]
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[Various neurochemical mechanisms for the production of conditioned reflexes of various biologicals modalities at the level of the caudate nucleus].[尾状核水平上各种生物学模态条件反射产生的多种神经化学机制]
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引用本文的文献

1
The influence on the realization of alimentary conditioned reflexes of the chronic injection of leu-enkephalin and its analog tetrapeptide into the caudate nucleus of dogs.向犬的尾状核慢性注射亮氨酸脑啡肽及其类似物四肽对食物性条件反射实现的影响。
Neurosci Behav Physiol. 1993 Jul-Aug;23(4):326-7. doi: 10.1007/BF01183022.
2
The influence of chronic activation and blockade of the dopamine- and enkephalinergic systems of the neostriatum on conditioned reflex behavior and dopamine metabolism in the rat nigrostriatal system.新纹状体中多巴胺能和脑啡肽能系统的慢性激活与阻断对大鼠黑质纹状体系统中条件反射行为及多巴胺代谢的影响。
Neurosci Behav Physiol. 1993 Nov-Dec;23(6):497-502. doi: 10.1007/BF01153675.
3
The participation of mediator and peptidergic systems of the brain in conditioned reflex mechanisms.
Neurosci Behav Physiol. 1990 Jul-Aug;20(4):365-70. doi: 10.1007/BF01236334.