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[大鼠短暂性脑缺血后的条件反射转换]

[Conditioned reflex switching after brief cerebral ischemia in the rat].

作者信息

Nezlina N I

出版信息

Zh Vyssh Nerv Deiat Im I P Pavlova. 1987 Jan-Feb;37(1):135-41.

PMID:3577403
Abstract

In rats reanimated after 5-minute circulation stoppage, conditioned switching-over was elaborated in 8 months after resuscitation on the basis of an alimentary and a defensive instrumental reflexes acquired at earlier terms after resuscitation. Elaboration of switching-over, according to the percentage of correct reactions to a phasic and a tonic conditioned stimuli, proceeded in reanimated rats as in intact animals, but the reanimated rats had more wrong reactions during elaboration of switching-over and at acute and passive extinction. Acute extinction of alimentary and defensive conditioned reflexes involved in the switching-over went slower in reanimated rats than in the intact ones. A conclusion is made that rats with a short-term brain ischemia, retain some deficit of internal inhibition processes in a remote post-resuscitation period, manifested at conditioned switching-over.

摘要

在经历5分钟循环停止后复苏的大鼠中,在复苏后基于早期获得的食物性和防御性工具性反射,在复苏后8个月内形成了条件性转换。根据对相位性和紧张性条件刺激的正确反应百分比,条件性转换的形成在复苏大鼠中与正常动物一样进行,但复苏大鼠在条件性转换形成过程中以及在急性和被动消退时错误反应更多。参与条件性转换的食物性和防御性条件反射的急性消退在复苏大鼠中比在正常大鼠中进行得更慢。得出的结论是,经历短期脑缺血的大鼠在复苏后的远期仍存在一些内抑制过程的缺陷,这在条件性转换中表现出来。

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