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[血液循环停止5分钟后大鼠的条件反射]

[Conditioned reflexes in rats after 5-minute arrest of blood circulation].

作者信息

Nezlina N I, Mutuskina E A, Tolova S V

出版信息

Zh Vyssh Nerv Deiat Im I P Pavlova. 1987 Jul-Aug;37(4):741-9.

PMID:3673263
Abstract

Neurological recovery and conditioned activity were studied in rats resuscitated after five-minute circulation cessation caused by intrathoracal clamp of the heart vascular bundle. The dynamics of disappearance of neurological deficit was evaluated according a scale of 19 parameters of the general state of animals where number 100 meant the death of the brain and number 0 meant recovery. In the course of 8 months after resuscitation, in reanimated rats and simultaneously in intact (control) ones, an alimentary instrumental conditioned reflex was elaborated and then changed to a defensive one; passive and acute extinction of both reflexes was also carried out. In most of the rats the neurological recovery was completed rapidly within 3-4 hours. In reanimated animals, both instrumental conditioned reflexes were acquired in the same way as in the intact rats. Quantitative evaluation of the dynamics of conditioning and extinction allowed to see that elaboration of the alimentary reflex in reanimated rats proceeded faster and its change to the defensive one, and acute extinction of both kinds of conditioned reflexes went slower than in intact animals. A conclusion is drawn that even a short-term circulation cessation compatible with complete and rapid compensation of visible neurological disorders causes long-term disturbances of conditioned activity manifested in weakening of inhibitory processes.

摘要

对因胸腔内钳夹心血管束导致心脏停搏五分钟后复苏的大鼠的神经恢复和条件活动进行了研究。根据动物一般状态的19项参数量表评估神经功能缺损消失的动态变化,其中100表示脑死亡,0表示恢复。在复苏后的8个月内,对复苏的大鼠以及同时的完整(对照)大鼠进行了食物性工具性条件反射的建立,然后将其转变为防御性条件反射;还对两种反射进行了被动和急性消退实验。在大多数大鼠中,神经恢复在3-4小时内迅速完成。在复苏的动物中,两种工具性条件反射的获得方式与完整大鼠相同。对条件反射建立和消退动态的定量评估表明,复苏大鼠中食物性反射的建立速度更快,其转变为防御性反射以及两种条件反射的急性消退速度比完整动物慢。得出的结论是,即使是与明显神经功能障碍的完全快速代偿相容的短期循环停止,也会导致条件活动的长期紊乱,表现为抑制过程的减弱。

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