Wu Jiajia, Rountree Corey M, Kare Sai-Siva, Ramkumar Pradeep Kumar, Finan John D, Troy John B
Department of Biomedical Engineering, Robert R. McCormick School of Engineering and Applied Science, Northwestern University, Evanston, IL, United States.
Department of Mechanical and Industrial Engineering, College of Engineering, University of Illinois at Chicago, Chicago, IL, United States.
Front Cell Neurosci. 2022 Jun 10;16:898865. doi: 10.3389/fncel.2022.898865. eCollection 2022.
The last major review of progress toward a chemical retinal prosthesis was a decade ago. Many important advancements have been made since then with the aim of producing an implantable device for animal testing. We review that work here discussing the potential advantages a chemical retinal prosthesis may possess, the spatial and temporal resolutions it might provide, the materials from which an implant might be constructed and its likely effectiveness in stimulating the retina in a natural fashion. Consideration is also given to implant biocompatibility, excitotoxicity of dispensed glutamate and known changes to photoreceptor degenerate retinas.
上一次对化学视网膜假体进展的重大评估是在十年前。从那时起，为了制造一种可植入动物进行测试的设备，已经取得了许多重要进展。我们在此回顾这项工作，讨论化学视网膜假体可能具有的潜在优势、它可能提供的空间和时间分辨率、植入物可能由哪些材料制成以及其以自然方式刺激视网膜的可能效果。还考虑了植入物的生物相容性、释放的谷氨酸的兴奋性毒性以及光感受器退化视网膜的已知变化。
