Xiong Hongting, Sun Hongyan, Zhou Jiangping, Li Haotian, Zhang Hao, Liu Shaojie, Cai Jiahua, Feng Lin, Miao Jungang, Chen Sai, Wu Xiaojun
School of Electronic and Information Engineering, Beihang University, 37 Xueyuan Road, Beijing 100191, China.
School of Mechanical Engineering and Automation, Beihang University (Shahe Campus), 9 Nansan Street, Shahe Higher Education Park, Changping, Beijing 102206, China.
Biomed Opt Express. 2022 Apr 4;13(5):2605-2615. doi: 10.1364/BOE.454338. eCollection 2022 May 1.
Terahertz (THz) spectroscopy provides multifaceted capabilities for observing low-energy responses of macromolecules, cells and tissues, understanding THz biophysical effects, and expecting to realize the application of THz technology in biomedicine. However, its high-frequency characteristics of limited penetration depth and strong absorption of water in the body comparable to microwaves are impeding the proliferation of THz spectroscopy. Here we show that THz spectroscopy makes possible the observation of THz anisotropy phenomena for the first time in fascia and lean tissue. Through optical microscopy, we infer that the microscopic mechanism of THz anisotropy comes from the periodic stripe structure of the biological tissue. The above related experimental findings may be expected to promote the application of THz technology in biomedicine.
太赫兹(THz)光谱为观察大分子、细胞和组织的低能量响应、理解太赫兹生物物理效应以及期望实现太赫兹技术在生物医学中的应用提供了多方面的能力。然而,其穿透深度有限的高频特性以及与微波相当的体内水的强吸收特性阻碍了太赫兹光谱的推广。在此我们表明,太赫兹光谱首次使在筋膜和瘦肉组织中观察到太赫兹各向异性现象成为可能。通过光学显微镜,我们推断太赫兹各向异性的微观机制源于生物组织的周期性条纹结构。上述相关实验结果有望促进太赫兹技术在生物医学中的应用。