Zhan Xinyu, Liu Yu, Chen Zhiguo, Luo Jie, Yang Sha, Yang Xiang
Department of Laboratory Medicine, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, 400038, China.
Department of Gastroenterology, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, 400037, China.
Talanta. 2023 Jul 1;259:124483. doi: 10.1016/j.talanta.2023.124483. Epub 2023 Mar 29.
Most tumors are easily missed and misdiagnosed due to the lack of specific clinical signs and symptoms in the early stage. Thus, an accurate, rapid and reliable early tumor detection method is highly desirable. The application of terahertz (THz) spectroscopy and imaging in biomedicine has made remarkable progress in the past two decades, which addresses the shortcomings of existing technologies and provides an alternative for early tumor diagnosis. Although issues such as size mismatch and strong absorption of THz waves by water have set hurdles for cancer diagnosis by THz technology, innovative materials and biosensors in recent years have led to possibilities for new THz biosensing and imaging methods. In this article, we reviewed the issues that need to be solved before THz technology is used for tumor-related biological sample detection and clinical auxiliary diagnosis. We focused on the recent research progress of THz technology, with an emphasis on biosensing and imaging. Finally, the application of THz spectroscopy and imaging for tumor diagnosis in clinical practice and the main challenges in this process were also mentioned. Collectively, THz-based spectroscopy and imaging reviewed here is envisioned as a cutting-edge approach for cancer diagnosis.
大多数肿瘤在早期由于缺乏特异性的临床体征和症状，很容易被漏诊和误诊。因此，非常需要一种准确、快速且可靠的早期肿瘤检测方法。太赫兹（THz）光谱学和成像技术在生物医学领域的应用在过去二十年中取得了显著进展，它弥补了现有技术的不足，并为早期肿瘤诊断提供了一种替代方法。尽管诸如尺寸不匹配以及太赫兹波在水中的强吸收等问题给太赫兹技术用于癌症诊断设置了障碍，但近年来创新材料和生物传感器为新型太赫兹生物传感和成像方法带来了可能性。在本文中，我们回顾了太赫兹技术用于肿瘤相关生物样本检测和临床辅助诊断之前需要解决的问题。我们聚焦于太赫兹技术的最新研究进展，重点是生物传感和成像。最后，还提到了太赫兹光谱学和成像在临床实践中用于肿瘤诊断的应用以及这一过程中的主要挑战。总体而言，本文所综述的基于太赫兹的光谱学和成像被视为一种用于癌症诊断的前沿方法。
