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通过评估肠道微生物群和代谢组学分析探讨小承气汤对慢传输型便秘的影响。

Effects of Xiao Chengqi Formula on Slow Transit Constipation by Assessing Gut Microbiota and Metabolomics Analysis and .

作者信息

Zhou Qian, Zhang Di, Zhang Heng, Wan Xingyang, Hu Bang, Zou Qi, Su Dan, Peng Hui, Huang Dandan, Ren Donglin

机构信息

Department of Coloproctology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

出版信息

Front Pharmacol. 2022 Jun 8;13:864598. doi: 10.3389/fphar.2022.864598. eCollection 2022.

DOI:10.3389/fphar.2022.864598
PMID:35774604
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9237644/
Abstract

The Xiao Chengqi (XCQ) formula is a newly constituted traditional Chinese medicine prescription in the treatment of intestinal motility deficiency and is effective in patients with slow transit constipation (STC). XCQ formula was reconstructed based on a "Chengqi" decoction. Astragali Radix, Angelicae Sinensis Radix, and cooked ground Salviae Miltiorrhizae Radix et Rhizoma were added to the prescription to enhance. An STC rat model was constructed and treated with the formula to understand the detailed mechanism by which XCQ promotes intestinal peristalsis. The effects of the XCQ formula on intestinal microflora and metabolic levels and the possible molecular mechanism of its regulation were explored using 16S rDNA sequencing, metabolomics sequencing, and tissue RNA sequencing. The results showed a significant decrease in the abundance of spp. in the feces of STC rats, a significant decrease in the content of butyl aminobenzene (BAB) in feces, and an increase in the number of interstitial cells of Cajal (ICC) in the colon of STC rats. Furthermore, and experiments revealed that BAB could activate IL-21R on the ICC surface, upregulate the phosphorylation of the downstream molecules STAT3 and ERK, and inhibit loperamide-induced ICC apoptosis. Therefore, the XCQ formula can improve the defecation status of patients with STC by protecting ICC activity, promoting the colonization of spp to promote peristalsis and increasing the BAB content after metabolism.

摘要

小承气（XCQ）方是一种新组成的用于治疗肠道动力不足的中药方剂，对慢传输型便秘（STC）患者有效。XCQ方是在“承气”汤的基础上重构而成。方中加入黄芪、当归、熟地黄丹参以增强疗效。构建STC大鼠模型并用该方进行治疗，以了解XCQ促进肠道蠕动的详细机制。采用16S rDNA测序、代谢组学测序和组织RNA测序，探讨XCQ方对肠道微生物群和代谢水平的影响及其可能的调控分子机制。结果显示，STC大鼠粪便中 spp. 的丰度显著降低，粪便中丁基氨基苯（BAB）含量显著降低，STC大鼠结肠中Cajal间质细胞（ICC）数量增加。此外， 和 实验表明，BAB可激活ICC表面的IL-21R，上调下游分子STAT3和ERK的磷酸化，并抑制洛哌丁胺诱导的ICC凋亡。因此，XCQ方可以通过保护ICC活性、促进 spp. 定殖以促进蠕动以及代谢后增加BAB含量来改善STC患者的排便状况。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2eaa/9237644/b67d8cf4f3ee/fphar-13-864598-g010.jpg
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