Huang Chen, Wu Qiong, Liang Jiabin, Wang Qian, He Xueping, Xie Yanqiu, Lu Yanbing, Su Jianfen, Tang Yutuan
Department of Minimally Invasive Interventional Radiology, Guangzhou Panyu Central Hospital, Guangzhou, China.
Medical Imaging Institute of Panyu, Guangzhou, China.
Front Pharmacol. 2022 Jun 14;13:935117. doi: 10.3389/fphar.2022.935117. eCollection 2022.
This study examined the dose-effect relationship of chitosan and danshen combined injections on the long-term prevention of fallopian tube re-obstructions, with increased pregnancy rates in infertile women. High-performance liquid chromatography was used to determine the content changes of combined chitosan and danshen injection. Two hundred and eighty patients with fallopian tube obstructions were randomly assigned to four groups. Group A (control group, saline), Group B (2 ml chitosan, 4 ml danshen), Group C (2 ml chitosan, 10 ml danshen), and Group D (1 ml chitosan, 10 ml danshen). Injections were administered after tubal recanalization. The effective constituent of chitosan and danshen injection was stable. Tubal patency rate was 94.2% and 87.3% in Group C after 1 and 3 years, respectively, which was significantly higher than Groups A (38.6%, 31.5%), B (73.5%, 64.1%), and D (68.5%, 50.7%). Intrauterine pregnancy rates were 61.8% and 79.4% in Group C after 1 and 3 years, respectively, and were significantly higher than Groups A (31.8%, 34.8%), B (40.1%, 62.5%), and D (38.5%, 58.5%) ( < 0.05). Combined Chitosan and danshen injections prevented tubal obstruction and increased pregnancy rates for long periods using an optimal ratio of 1 part chitosan and 5 parts danshen.
本研究探讨了壳聚糖与丹参联合注射对输卵管再阻塞的长期预防作用及对不孕女性妊娠率的影响。采用高效液相色谱法测定壳聚糖与丹参联合注射液的含量变化。将280例输卵管阻塞患者随机分为四组。A组（对照组，生理盐水），B组（2ml壳聚糖，4ml丹参），C组（2ml壳聚糖，10ml丹参），D组（1ml壳聚糖，10ml丹参）。输卵管再通后进行注射。壳聚糖与丹参注射液的有效成分稳定。C组1年和3年后输卵管通畅率分别为94.2%和87.3%，显著高于A组（38.6%，31.5%）、B组（73.5%，64.1%）和D组（68.5%，50.7%）。C组1年和3年后宫内妊娠率分别为61.8%和79.4%，显著高于A组（31.8%，34.8%）、B组（40.1%，62.5%）和D组（38.5%，58.5%）（P<0.05）。壳聚糖与丹参联合注射以1份壳聚糖与5份丹参的最佳比例可长期预防输卵管阻塞并提高妊娠率。
