• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

以心动过缓、肾衰竭、房室结阻滞、休克和高钾血症综合征为临床特征诊断转甲状腺素蛋白淀粉样变性：两例报告

Bradycardia, Renal Failure, Atrioventricular Nodal Blockade, Shock, and Hyperkalemia Syndrome as a Clinical Profile Leading to the Diagnosis of Transthyretin Amyloidosis: A Report of Two Cases.

作者信息

Takahashi Koji, Sakaue Tomoki, Uemura Shigeki, Okura Takafumi, Ikeda Shuntaro

机构信息

Department of Cardiology, Yawatahama City General Hospital, Ehime, JPN.

Department of Community Emergency Medicine, Ehime University Graduate School of Medicine, Ehime, JPN.

出版信息

Cureus. 2022 May 29;14(5):e25444. doi: 10.7759/cureus.25444. eCollection 2022 May.

DOI:10.7759/cureus.25444
PMID:35774664
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9238110/
Abstract

We describe two cases in which the onset of bradycardia, renal failure, atrioventricular (AV) nodal blockade, shock, and hyperkalemia (BRASH) syndrome led to the diagnosis of transthyretin cardiac amyloidosis. In Case 1, BRASH syndrome developed shortly after a therapeutic dose of AV nodal blockers was prescribed for new-onset atrial flutter. BRASH syndrome improved with intravenous dopamine infusion and temporary cardiac pacing. In Case 2, BRASH syndrome developed immediately after bronchopneumonia followed by worsening heart failure, despite no change in medications such as AV nodal blockers. Intravenous injection of calcium dramatically improved BRASH syndrome.

摘要

我们描述了两例病例，其中心动过缓、肾衰竭、房室（AV）结阻滞、休克和高钾血症（BRASH）综合征的发作导致了转甲状腺素蛋白心脏淀粉样变性的诊断。在病例1中，在为新发心房扑动开具治疗剂量的AV结阻滞剂后不久，BRASH综合征就出现了。静脉输注多巴胺和临时心脏起搏后，BRASH综合征有所改善。在病例2中，尽管AV结阻滞剂等药物没有变化，但支气管肺炎后立即出现BRASH综合征，随后心力衰竭加重。静脉注射钙剂使BRASH综合征显著改善。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7588/9238110/9a1255768417/cureus-0014-00000025444-i08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7588/9238110/04712b74246d/cureus-0014-00000025444-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7588/9238110/66a2d2b22fc7/cureus-0014-00000025444-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7588/9238110/7839f66285b6/cureus-0014-00000025444-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7588/9238110/776dd374ece8/cureus-0014-00000025444-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7588/9238110/d18a03b27ebf/cureus-0014-00000025444-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7588/9238110/f88468d71118/cureus-0014-00000025444-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7588/9238110/a4e1011bedff/cureus-0014-00000025444-i07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7588/9238110/9a1255768417/cureus-0014-00000025444-i08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7588/9238110/04712b74246d/cureus-0014-00000025444-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7588/9238110/66a2d2b22fc7/cureus-0014-00000025444-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7588/9238110/7839f66285b6/cureus-0014-00000025444-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7588/9238110/776dd374ece8/cureus-0014-00000025444-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7588/9238110/d18a03b27ebf/cureus-0014-00000025444-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7588/9238110/f88468d71118/cureus-0014-00000025444-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7588/9238110/a4e1011bedff/cureus-0014-00000025444-i07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7588/9238110/9a1255768417/cureus-0014-00000025444-i08.jpg

相似文献

1
Bradycardia, Renal Failure, Atrioventricular Nodal Blockade, Shock, and Hyperkalemia Syndrome as a Clinical Profile Leading to the Diagnosis of Transthyretin Amyloidosis: A Report of Two Cases.以心动过缓、肾衰竭、房室结阻滞、休克和高钾血症综合征为临床特征诊断转甲状腺素蛋白淀粉样变性：两例报告
Cureus. 2022 May 29;14(5):e25444. doi: 10.7759/cureus.25444. eCollection 2022 May.
2
Transthyretin Cardiac Amyloidosis Presenting as Bradycardia, Renal Failure, Atrioventricular-Nodal Blockade, Shock, and Hyperkalemia (BRASH) Syndrome: A Case Report.以心动过缓、肾衰竭、房室传导阻滞、休克和高钾血症（BRASH）综合征为表现的转甲状腺素蛋白心脏淀粉样变性：一例报告
Cureus. 2023 Sep 1;15(9):e44532. doi: 10.7759/cureus.44532. eCollection 2023 Sep.
3
BRASH Syndrome: Bradycardia, Renal Failure, AV Blockade, Shock, and Hyperkalemia.BRASH 综合征：心动过缓、肾衰竭、房室传导阻滞、休克和高钾血症。
J Emerg Med. 2020 Aug;59(2):216-223. doi: 10.1016/j.jemermed.2020.05.001. Epub 2020 Jun 18.
4
A Combination of Beta-Blockade and Calcium Channel Blockade Leading to Bradycardia, Renal Failure, Atrioventricular Blockade, Shock, and Hyperkalemia (BRASH) Syndrome: A Case Report.β受体阻滞剂与钙通道阻滞剂联合使用导致心动过缓、肾衰竭、房室传导阻滞、休克和高钾血症（BRASH）综合征：一例报告
Cureus. 2023 Jun 9;15(6):e40176. doi: 10.7759/cureus.40176. eCollection 2023 Jun.
5
Bradycardia, Renal Failure, Atrioventricular Nodal Blockade, Shock and Hyperkalemia (BRASH) Syndrome: A Clinical Case Study.心动过缓、肾衰竭、房室结阻滞、休克和高钾血症（BRASH）综合征：一项临床病例研究
Cureus. 2023 Feb 9;15(2):e34803. doi: 10.7759/cureus.34803. eCollection 2023 Feb.
6
Urinary Tract Infection Causing Bradycardia, Renal Failure, Atrioventricular Nodal Blockade, Shock, and Hyperkalemia (BRASH) Syndrome: A Case Report and a Brief Review of the Literature.尿路感染导致心动过缓、肾衰竭、房室结阻滞、休克和高钾血症（BRASH）综合征：一例报告及文献简要综述
Cureus. 2022 Aug 3;14(8):e27641. doi: 10.7759/cureus.27641. eCollection 2022 Aug.
7
The Role of Verapamil Toxicity in the Vicious Cycle of Bradycardia, Renal Failure, Atrioventricular Nodal Blockade, Shock, and Hyperkalemia (BRASH) Syndrome: A Case Report.维拉帕米中毒在心动过缓、肾衰竭、房室结阻滞、休克和高钾血症（BRASH）综合征恶性循环中的作用：一例报告
Cureus. 2022 Dec 8;14(12):e32336. doi: 10.7759/cureus.32336. eCollection 2022 Dec.
8
Bradycardia, Renal Failure, Atrioventricular-Nodal Blockade, Shock, and Hyperkalemia Syndrome: A Case Report.心动过缓、肾衰竭、房室结阻滞、休克及高钾血症综合征：一例报告
Cureus. 2022 Mar 25;14(3):e23486. doi: 10.7759/cureus.23486. eCollection 2022 Mar.
9
Clinical characteristics of BRASH syndrome: Systematic scoping review.BRASH 综合征的临床特征：系统范围综述。
Eur J Intern Med. 2022 Sep;103:57-61. doi: 10.1016/j.ejim.2022.06.002. Epub 2022 Jun 5.
10
Bradycardia, Renal Failure, Atrioventricular-nodal Blocker, Shock, and Hyperkalemia Syndrome Diagnosis and Literature Review.心动过缓、肾衰竭、房室结阻滞剂、休克及高钾血症综合征的诊断与文献综述
Cureus. 2020 Feb 13;12(2):e6985. doi: 10.7759/cureus.6985.

引用本文的文献

1
The Interplay Between Hypocalcemia and Atrioventricular Nodal Blocking Agents in Inducing a Bradycardia, Renal Failure, Atrioventricular Nodal Blockade, Shock, and Hyperkalemia (BRASH)-Like Phenomenon With Serial Serum Drug Concentrations.低钙血症与房室结阻滞剂在诱发心动过缓、肾衰竭、房室结阻滞、休克和高钾血症（BRASH）样现象及系列血清药物浓度方面的相互作用
Cureus. 2025 Feb 12;17(2):e78925. doi: 10.7759/cureus.78925. eCollection 2025 Feb.
2
Transthyretin Cardiac Amyloidosis Presenting as Bradycardia, Renal Failure, Atrioventricular-Nodal Blockade, Shock, and Hyperkalemia (BRASH) Syndrome: A Case Report.以心动过缓、肾衰竭、房室传导阻滞、休克和高钾血症（BRASH）综合征为表现的转甲状腺素蛋白心脏淀粉样变性：一例报告
Cureus. 2023 Sep 1;15(9):e44532. doi: 10.7759/cureus.44532. eCollection 2023 Sep.

本文引用的文献

1
Amyloid deposit corresponds to technetium-99m-pyrophosphate accumulation in abdominal fat of patients with transthyretin cardiac amyloidosis.淀粉样蛋白沉积物与转甲状腺素蛋白心脏淀粉样变性患者腹部脂肪中99m锝焦磷酸盐的积聚相对应。
J Nucl Cardiol. 2022 Dec;29(6):3126-3136. doi: 10.1007/s12350-021-02890-6. Epub 2021 Dec 28.
2
Diagnosis and treatment of cardiac amyloidosis: a position statement of the ESC Working Group on Myocardial and Pericardial Diseases.心脏淀粉样变性的诊断与治疗：欧洲心脏病学会心肌与心包疾病工作组的立场声明
Eur Heart J. 2021 Apr 21;42(16):1554-1568. doi: 10.1093/eurheartj/ehab072.
3
BRASH Syndrome: A Case Report.
BRASH 综合征：一例报告。
J Emerg Med. 2021 Jun;60(6):818-822. doi: 10.1016/j.jemermed.2021.01.033. Epub 2021 Feb 24.
4
Congestive Hepatopathy.充血性肝病。
Int J Mol Sci. 2020 Dec 10;21(24):9420. doi: 10.3390/ijms21249420.
5
BRASH Syndrome with Hyperkalemia: An Under-Recognized Clinical Condition.伴有高钾血症的BRASH综合征：一种未被充分认识的临床病症。
Methodist Debakey Cardiovasc J. 2020 Jul-Sep;16(3):241-244. doi: 10.14797/mdcj-16-3-241.
6
JCS 2020 Guideline on Diagnosis and Treatment of Cardiac Amyloidosis.《日本循环学会2020年心脏淀粉样变性诊断与治疗指南》
Circ J. 2020 Aug 25;84(9):1610-1671. doi: 10.1253/circj.CJ-20-0110. Epub 2020 Aug 21.
7
BRASH Syndrome: Bradycardia, Renal Failure, AV Blockade, Shock, and Hyperkalemia.BRASH 综合征：心动过缓、肾衰竭、房室传导阻滞、休克和高钾血症。
J Emerg Med. 2020 Aug;59(2):216-223. doi: 10.1016/j.jemermed.2020.05.001. Epub 2020 Jun 18.
8
Estimating the Prevalence of Transthyretin Amyloid Cardiomyopathy in a Large In-Hospital Database in Japan.在日本一个大型医院数据库中估算转甲状腺素蛋白淀粉样心肌病的患病率。
Cardiol Ther. 2019 Dec;8(2):297-316. doi: 10.1007/s40119-019-0142-5. Epub 2019 Aug 2.
9
Electrophysiology of Hypokalemia and Hyperkalemia.低钾血症和高钾血症的电生理学
Circ Arrhythm Electrophysiol. 2017 Mar;10(3). doi: 10.1161/CIRCEP.116.004667.
10
Echo Parameters for Differential Diagnosis in Cardiac Amyloidosis: A Head-to-Head Comparison of Deformation and Nondeformation Parameters.心脏淀粉样变性鉴别诊断中的超声心动图参数：变形参数与非变形参数的直接比较
Circ Cardiovasc Imaging. 2017 Mar;10(3):e005588. doi: 10.1161/CIRCIMAGING.116.005588.