伴有高钾血症的BRASH综合征：一种未被充分认识的临床病症。
BRASH Syndrome with Hyperkalemia: An Under-Recognized Clinical Condition.
作者信息
Arif Abdul Wahab, Khan Muhammad Shahzeb, Masri Abdallah, Mba Benjamin, Talha Ayub Muhammad, Doukky Rami
机构信息
COOK COUNTY HOSPITAL, CHICAGO, ILLINOIS.
RUSH UNIVERSITY MEDICAL CENTER, CHICAGO, ILLINOIS.
出版信息
Methodist Debakey Cardiovasc J. 2020 Jul-Sep;16(3):241-244. doi: 10.14797/mdcj-16-3-241.
Abstract
BRASH syndrome is characterized by bradycardia, renal failure, use of an atrioventricular nodal blocker (AVNB), shock, and hyperkalemia. These symptoms represent an ongoing vicious cycle in a patient with a low glomerular filtration rate taking an AVNB. Decreased clearance of the medication and hyperkalemia associated with renal failure synergize to cause bradycardia and hypoperfusion. This reaction causes renal function to worsen, thereby perpetuating the cycle of BRASH syndrome.
摘要
BRASH综合征的特征为心动过缓、肾衰竭、使用房室结阻滞剂（AVNB）、休克和高钾血症。这些症状在肾小球滤过率低且正在服用AVNB的患者中代表着一个持续的恶性循环。药物清除率降低以及与肾衰竭相关的高钾血症共同作用导致心动过缓和灌注不足。这种反应会使肾功能恶化，从而使BRASH综合征的循环持续下去。
相似文献
1
BRASH Syndrome with Hyperkalemia: An Under-Recognized Clinical Condition.
Methodist Debakey Cardiovasc J. 2020 Jul-Sep;16(3):241-244. doi: 10.14797/mdcj-16-3-241.
2
BRASH Syndrome: Bradycardia, Renal Failure, AV Blockade, Shock, and Hyperkalemia.
J Emerg Med. 2020 Aug;59(2):216-223. doi: 10.1016/j.jemermed.2020.05.001. Epub 2020 Jun 18.
3
When a Cure Becomes a Curse: The Complex Clinical Scenario Involving Amiodarone Therapy and BRASH (Bradycardia, Renal failure, Atrioventricular Nodal Blockade, Shock, and Hyperkalemia) Syndrome.
Cureus. 2023 May 6;15(5):e38622. doi: 10.7759/cureus.38622. eCollection 2023 May.
4
Bradycardia, Renal Failure, Atrioventricular-Nodal Blockade, Shock, and Hyperkalemia Syndrome: A Case Report.
Cureus. 2022 Mar 25;14(3):e23486. doi: 10.7759/cureus.23486. eCollection 2022 Mar.
5
Bradycardia, Renal Failure, Atrioventricular-nodal Blocker, Shock, and Hyperkalemia Syndrome Diagnosis and Literature Review.
Cureus. 2020 Feb 13;12(2):e6985. doi: 10.7759/cureus.6985.
6
Bradycardia, Renal Failure, Atrioventricular Nodal Blockade, Shock and Hyperkalemia (BRASH) Syndrome: A Clinical Case Study.
Cureus. 2023 Feb 9;15(2):e34803. doi: 10.7759/cureus.34803. eCollection 2023 Feb.
7
Anaphylaxis induced bradycardia, renal failure, AV-nodal blockade, shock, and hyperkalemia: A-BRASH in the emergency department.
Am J Emerg Med. 2020 Sep;38(9):1987.e1-1987.e3. doi: 10.1016/j.ajem.2020.05.033. Epub 2020 May 16.
8
BRASH syndrome with a complete heart block- a case report.
BMC Cardiovasc Disord. 2024 Feb 19;24(1):114. doi: 10.1186/s12872-024-03782-6.
9
The Role of Verapamil Toxicity in the Vicious Cycle of Bradycardia, Renal Failure, Atrioventricular Nodal Blockade, Shock, and Hyperkalemia (BRASH) Syndrome: A Case Report.
Cureus. 2022 Dec 8;14(12):e32336. doi: 10.7759/cureus.32336. eCollection 2022 Dec.
10
The BRASH syndrome: an interaction of bradycardia, renal failure, AV block, shock and hyperkalemia.
Intern Emerg Med. 2021 Mar;16(2):509-511. doi: 10.1007/s11739-020-02452-7. Epub 2020 Jul 25.
引用本文的文献
1
Critical presentation of bradycardia, renal failure, atrioventricular nodal blockade, shock, and hyperkalemia syndrome: A case report.
World J Clin Cases. 2025 Sep 6;13(25):107948. doi: 10.12998/wjcc.v13.i25.107948.
2
Challenges in the Management of Bradycardia, Renal Failure, Atrioventricular Blockade, Shock, and Hyperkalemia (BRASH) Syndrome in an Elderly Patient: A Case Report.
Cureus. 2025 Apr 16;17(4):e82364. doi: 10.7759/cureus.82364. eCollection 2025 Apr.
3
A Case of BRASH Syndrome Required Two Hospitalizations in a Short Period.
Cureus. 2024 Oct 30;16(10):e72731. doi: 10.7759/cureus.72731. eCollection 2024 Oct.
4
BRASH (Bradycardia, Renal Failure, Atrioventricular Nodal Blockade, Shock, and Hyperkalemia) Syndrome: A Frequently Underrecognized Condition Often Confused With Simple Hyperkalemia.
Cureus. 2024 Aug 29;16(8):e68106. doi: 10.7759/cureus.68106. eCollection 2024 Aug.
5
Bradycardia, Renal Dysfunction, Atrioventricular Nodal Blockade, Shock, and Hyperkalemia (BRASH) Syndrome: A Case Report Highlighting the Importance of Early Recognition and Management.
Cureus. 2024 Mar 10;16(3):e55892. doi: 10.7759/cureus.55892. eCollection 2024 Mar.
6
Bradycardia, Renal Failure, Atrioventricular Block, Shock, and Hyperkalemia (BRASH) Syndrome Emergence in a Unique Intersection of COVID-19 and End-Stage Renal Disease: A Case Report.
Cureus. 2024 Feb 22;16(2):e54695. doi: 10.7759/cureus.54695. eCollection 2024 Feb.
7
A Case of Bradycardia, Renal Failure, Atrioventricular Nodal Blockade, Shock, and Hyperkalaemia (BRASH) Syndrome in an Elderly Male and Its Management: A Case Report and Literature Review.
Cureus. 2023 Nov 27;15(11):e49489. doi: 10.7759/cureus.49489. eCollection 2023 Nov.
8
Bradycardia, Renal Failure, Atrioventricular Nodal Blockade, Shock and Hyperkalaemia Syndrome Involving Digoxin Toxicity: A Case Report.
Heart Int. 2023 Jun 8;17(1):60-62. doi: 10.17925/HI.2023.17.1.60. eCollection 2023.
9
Rare presentation of BRASH syndrome with hypoglycemia and altered mental status.
Int J Emerg Med. 2023 Jul 3;16(1):42. doi: 10.1186/s12245-023-00517-w.
10
When a Cure Becomes a Curse: The Complex Clinical Scenario Involving Amiodarone Therapy and BRASH (Bradycardia, Renal failure, Atrioventricular Nodal Blockade, Shock, and Hyperkalemia) Syndrome.
Cureus. 2023 May 6;15(5):e38622. doi: 10.7759/cureus.38622. eCollection 2023 May.
本文引用的文献
1
Bradycardia, Renal Failure, Atrioventricular Nodal Blockade, Shock, and Hyperkalemia (BRASH) Syndrome as a Presentation of Coronavirus Disease 2019.
Cureus. 2020 Apr 24;12(4):e7816. doi: 10.7759/cureus.7816.
2
Trimethoprim/Sulfamethoxazole-Induced Bradycardia, Renal Failure, AV-Node Blockers, Shock and Hyperkalemia Syndrome.
Clin Pract Cases Emerg Med. 2019 Jul 22;3(3):282-285. doi: 10.5811/cpcem.2019.5.43118. eCollection 2019 Aug.
3
Synergistic Bradycardia from Beta Blockers, Hyperkalemia, and Renal Failure.
J Emerg Med. 2019 Aug;57(2):e41-e44. doi: 10.1016/j.jemermed.2019.03.039. Epub 2019 May 30.
4
Junctional bradycardia with verapamil in renal failure--care required even with mild hyperkalaemia.
J Clin Pharm Ther. 2012 Dec;37(6):726-8. doi: 10.1111/j.1365-2710.2012.01352.x. Epub 2012 May 9.
Zotero 插件