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以心动过缓、肾衰竭、房室传导阻滞、休克和高钾血症（BRASH）综合征为表现的转甲状腺素蛋白心脏淀粉样变性：一例报告

Transthyretin Cardiac Amyloidosis Presenting as Bradycardia, Renal Failure, Atrioventricular-Nodal Blockade, Shock, and Hyperkalemia (BRASH) Syndrome: A Case Report.

作者信息

Khatun Nazima, Brown Bernard, Francois Jonathan, Budzikowski Adam S, Salciccioli Louis, John Sabu

机构信息

Department of Internal Medicine, State University of New York Downstate Health Sciences University, Brooklyn, USA.

Department of Cardiology, State University of New York Downstate Medical Center, Brooklyn, USA.

出版信息

Cureus. 2023 Sep 1;15(9):e44532. doi: 10.7759/cureus.44532. eCollection 2023 Sep.

DOI:10.7759/cureus.44532
PMID:37790068
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10544653/
Abstract

BRASH syndrome involves the chain of events resulting from the collective effects of radycardia, enal failure, trioventricular (AV)-nodal blockade, hock, and yperkalemia. BRASH syndrome can rapidly progress to cardiac arrest. Early recognition is crucial. We present a case of transthyretin cardiac amyloidosis (ATTR-CA) in an elderly woman who presented with BRASH syndrome shortly after an AV-nodal blocker was prescribed for atrial fibrillation.

摘要

BRASH综合征涉及由心动过缓、肾衰竭、房室结阻滞、休克和高钾血症的共同作用所引发的一系列事件。BRASH综合征可迅速进展为心脏骤停。早期识别至关重要。我们报告一例老年女性转甲状腺素蛋白心脏淀粉样变（ATTR-CA）病例，该患者在因心房颤动开具房室结阻滞剂后不久出现BRASH综合征。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c05e/10544653/b15560cc708c/cureus-0015-00000044532-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c05e/10544653/cac2e74c5c25/cureus-0015-00000044532-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c05e/10544653/531568fa3d3d/cureus-0015-00000044532-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c05e/10544653/b31d4e55c9a5/cureus-0015-00000044532-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c05e/10544653/b15560cc708c/cureus-0015-00000044532-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c05e/10544653/cac2e74c5c25/cureus-0015-00000044532-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c05e/10544653/531568fa3d3d/cureus-0015-00000044532-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c05e/10544653/b31d4e55c9a5/cureus-0015-00000044532-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c05e/10544653/b15560cc708c/cureus-0015-00000044532-i04.jpg

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本文引用的文献

1
Bradycardia, Renal Failure, Atrioventricular Nodal Blockade, Shock, and Hyperkalemia Syndrome as a Clinical Profile Leading to the Diagnosis of Transthyretin Amyloidosis: A Report of Two Cases.以心动过缓、肾衰竭、房室结阻滞、休克和高钾血症综合征为临床特征诊断转甲状腺素蛋白淀粉样变性：两例报告
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Bradycardia, Renal Failure, Atrioventricular-Nodal Blockade, Shock, and Hyperkalemia Syndrome: A Case Report.心动过缓、肾衰竭、房室结阻滞、休克及高钾血症综合征：一例报告
Cureus. 2022 Mar 25;14(3):e23486. doi: 10.7759/cureus.23486. eCollection 2022 Mar.
3
BRASH Syndrome: Bradycardia, Renal Failure, AV Blockade, Shock, and Hyperkalemia.
BRASH 综合征：心动过缓、肾衰竭、房室传导阻滞、休克和高钾血症。
J Emerg Med. 2020 Aug;59(2):216-223. doi: 10.1016/j.jemermed.2020.05.001. Epub 2020 Jun 18.
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Cardiac Amyloidosis: Evolving Diagnosis and Management: A Scientific Statement From the American Heart Association.心脏淀粉样变性：不断发展的诊断和治疗——美国心脏协会的科学声明。
Circulation. 2020 Jul 7;142(1):e7-e22. doi: 10.1161/CIR.0000000000000792. Epub 2020 Jun 1.
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Transthyretin cardiac amyloidosis: an update on diagnosis and treatment.转甲状腺素蛋白心脏淀粉样变：诊断与治疗的最新进展。
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