Wolff C, Verlohren H J, Arlt P, Mechmedowa F, Kripylo C, Wetzler C
Zentralbl Gynakol. 1987;109(2):88-97.
In 69 patients with a gestational diabetes-diagnosed by reproducible pathological results of two oral glucose loads (50 g) or by fasting blood glucose values of greater than or equal to 6.7 mmol/l in pregnancy the carbohydrate metabolism was checked postgestationally again with a glucose tolerance test (75 g) in a period of 6 weeks up to 2 years post partum. The postgestational classification showed the following results: manifested diabetes n = 15 (21.7%), impaired glucose tolerance n = 15 (21.7%), non-classificable disturbed carbohydrate tolerance n = 10 (14.5%), normal test results n = 29 (42%). The high rate of diabetic manifestations underlines the necessity of a postgestational classification of the so-called gestational diabetes controlled by the delivering center. The high risk of manifestation is calculable in the whole group, but not predictable for the single case. The risk is the higher the earlier a glucosuria in pregnancy can be found (before the 24th week), the earlier an insulinisation is necessary to guarantee a normoglycemia and the higher individual deviations of the individual blood glucose values during the daily course are observed (measurable with the glycemic index acc. Michaelis et al.). Additional risk factors are: obesity, an age over 30 years at the beginning of pregnancy, and heredity of first degree. From the retrospective point of view of a postgestational classification new therapeutic aspects could not be verified to avoid diabetes manifestation. Nevertheless an exact normoglycemic control and a very early start of treatment, a correct screening of risk factors and an immediate diagnosis of a gestational diabetes are a supposition to avert hyperglycemic dangers from the child.
对69例妊娠期糖尿病患者进行了研究,这些患者通过两次口服葡萄糖负荷试验(50克)的可重复性病理结果或孕期空腹血糖值大于或等于6.7毫摩尔/升确诊。产后6周内至产后2年期间,再次通过葡萄糖耐量试验(75克)对其碳水化合物代谢情况进行检查。产后分类结果如下:显性糖尿病n = 15(21.7%),糖耐量受损n = 15(21.7%),无法分类的碳水化合物耐量紊乱n = 10(14.5%),检查结果正常n = 29(42%)。糖尿病显性表现的高比例凸显了由分娩中心对所谓妊娠期糖尿病进行产后分类的必要性。在整个群体中,显性表现的高风险是可计算的,但对于单个病例则无法预测。妊娠期间越早发现糖尿(在第24周之前)、越早需要胰岛素治疗以确保血糖正常以及日常过程中个体血糖值的个体偏差越大(根据米夏埃利斯等人的血糖指数可测量),风险就越高。其他风险因素包括:肥胖、妊娠开始时年龄超过30岁以及一级亲属遗传。从产后分类的回顾性角度来看,无法证实有新的治疗方法可避免糖尿病的显性表现。然而,精确的血糖正常控制和极早开始治疗、正确筛查风险因素以及及时诊断妊娠期糖尿病是避免胎儿面临高血糖危险的前提。