Sananta Panji, Isnansyah Yun, Rosandi Rizqi D, Sugiarto Muhammad Alwy
Department of Orthopaedics and Traumatology, Dr Saiful Anwar General Hospital, Malang, Indonesia.
Acta Inform Med. 2022 Jun;30(2):121-124. doi: 10.5455/aim.2022.30.121-124.
Injury of growth plate may lead to serious complications such as bone bridge formation, deformity, growth disturbance, and limb length discrepancy. Stem cell therapy is one of the fields studied to mitigate this problem. There are various types and techniques which can be implemented.
This systematic review aims to review the most common techniques used in the experimental animal study about the application of stem cells to treat growth plate injury.
This study was conducted according to PRISMA guidelines. The following strategy was used. The terms used on the search engine were "stem cell growth plate injury" in PubMed database. A bibliometric evaluation was done on all the search results.
The initial PubMed search yielded 74 results, but 5 articles were eliminated because they could not be accessed. From the remaining 69 articles, 50 were excluded after abstract and full-text review. Further, 7 articles were eliminated because they did not meet the inclusion criteria. Most studies are experimental animal studies, and there is no human trial regarding this matter.
There are still a few studies evaluating the application of stem cell in treating growth plate injuries, but the present results are generally satisfactory. Hopefully, clinical trials could be conducted in the near future.
生长板损伤可能导致严重并发症，如骨桥形成、畸形、生长紊乱和肢体长度差异。干细胞疗法是为减轻这一问题而研究的领域之一。有多种类型和技术可供实施。
本系统评价旨在综述实验动物研究中应用干细胞治疗生长板损伤的最常用技术。
本研究按照PRISMA指南进行。采用了以下策略。在PubMed数据库中，搜索引擎使用的检索词为“干细胞生长板损伤”。对所有检索结果进行了文献计量学评估。
PubMed的初始检索产生了74条结果，但5篇文章因无法获取而被排除。在对其余69篇文章进行摘要和全文审查后，排除了50篇。此外，7篇文章因不符合纳入标准而被排除。大多数研究是实验动物研究，目前尚无关于此事的人体试验。
评估干细胞在治疗生长板损伤中应用的研究仍然较少，但目前的结果总体上令人满意。希望在不久的将来能够开展临床试验。
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