Vascular & Endovascular Surgery, Velindre University NHS Trust, Health Education & Improvement Wales (HEIW), Cardiff, UK.
Institute of Cardiac and Aortic Disorders (ICAD), SRM Institutes for Medical Science (SIMS Hospital), Chennai, Tamil Nadu, India.
J Card Surg. 2022 Sep;37(9):2761-2765. doi: 10.1111/jocs.16728. Epub 2022 Jul 1.
Acute type B aortic dissection (TBAD) is a rare condition that can be divided into complicated (CoTBAD) and uncomplicated (UnCoTBAD) based on certain presenting clinical and radiological features, with UnCoTBAD constituting the majority of TBAD cases. The classification of TBAD directly affects the treatment pathway taken, however, there remains confusion as to exactly what differentiates complicated from uncomplicated TBAD.
The scope of this review is to delineate the literature defining the intervention parameters for UnCoTBAD.
A comprehensive literature search was conducted using multiple electronic databases including PubMed, Scopus, and EMBASE to collate and summarize all research evidence on intervention parameters and protocols for UnCoTBAD.
A TBAD without evidence of malperfusion or rupture might be classified as uncomplicated but there remains a subgroup who might exhibit high-risk features. Two clinical features representative of "high risk" are refractory pain and persistent hypertension. First-line treatment for CoTBAD is TEVAR, and whilst this has also proven its safety and effectiveness in UnCoTBAD, it is still being managed conservatively. However, TBAD is a dynamic pathology and a significant proportion of UnCoTBADs can progress to become complicated, thus necessitating more complex intervention. While the "high-risk" UnCoTBAD do benefit the most from TEVAR, yet, the defining parameters are still debatable as this benefit can be extended to a wider UnCoTBAD population.
Uncomplicated TBAD remains a misnomer as it is frequently representative of a complex ongoing disease process requiring very close monitoring in a critical care setting. A clear diagnostic pathway may improve decision making following a diagnosis of UnCoTBAD. Choice of treatment still predominantly depends on when an equilibrium might be reached where the risks of TEVAR outweigh the natural history of the dissection in both the short- and long-term.
急性 B 型主动脉夹层(TBAD)是一种罕见的疾病,可以根据某些临床表现和影像学特征分为复杂型(CoTBAD)和非复杂型(UnCoTBAD),其中 UnCoTBAD 构成了大多数 TBAD 病例。TBAD 的分类直接影响治疗途径,但对于复杂型和非复杂型 TBAD 的具体区别仍存在混淆。
本综述的范围是阐明文献中对 UnCoTBAD 干预参数的定义。
通过多个电子数据库(包括 PubMed、Scopus 和 EMBASE)进行全面的文献检索,以汇集和总结所有关于 UnCoTBAD 干预参数和方案的研究证据。
没有灌注不良或破裂证据的 TBAD 可能被归类为非复杂型,但仍存在一个可能表现出高危特征的亚组。两个代表“高危”的临床特征是难治性疼痛和持续高血压。CoTBAD 的一线治疗是 TEVAR,虽然它在 UnCoTBAD 中也已证明安全有效,但仍在保守治疗。然而,TBAD 是一种动态病理学,相当一部分 UnCoTBAD 可能进展为复杂型,因此需要更复杂的干预。虽然“高危”UnCoTBAD 确实从 TEVAR 中获益最多,但定义参数仍存在争议,因为这种获益可以扩展到更广泛的 UnCoTBAD 人群。
非复杂型 TBAD 仍然是一个误解,因为它经常代表一个复杂的进行性疾病过程,需要在重症监护环境中进行非常密切的监测。明确的诊断途径可能会改善 UnCoTBAD 诊断后的决策制定。治疗选择仍然主要取决于何时可能达到平衡,即 TEVAR 的风险超过夹层在短期和长期的自然史。