Department of Orthopedics, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing, People's Republic of China.
Eur Rev Med Pharmacol Sci. 2022 Jun;26(12):4197-4206. doi: 10.26355/eurrev_202206_29056.
The aim of this paper was to evaluate the effects of robot-assisted core decompression combined with human umbilical cord-derived mesenchymal stem cell (hUC-MSC) transplantation for early-stage osteonecrosis of the femoral head (ONFH).
A retrospective analysis was performed on 18 patients with a total of 26 hips who were diagnosed with Association Research Circulation Osseous stage 2 avascular necrosis of the femoral head and who received core decompression combined with hUC-MSC transplantation. All surgeries were completed under robotic assistance. Preoperative and postoperative visual analogue scale (VAS) scores and the Harris Hip Score (HHS) were recorded to assess clinical function. A Magnetic Resonance Imaging (MRI) examination was performed at the last follow-up.
The mean follow-up was 18.6 months (12-28 months), the VAS score (4.5±0.8 vs. 0.9±0.2, t=12.6, p≤0.001) and HHS (79.5±5.8 vs. 60.5±4.6, t=14.3, p≤0.001) were significantly improved at the last follow-up, compared with preoperative value. The MRI results showed that the necrotic volume of the femoral heads was significantly reduced.
Robot-assisted core decompression combined with hUC-MSC transplantation is a feasible and relatively safe method for the treatment of femoral head necrosis.
本文旨在评估机器人辅助核心减压联合人脐带间充质干细胞（hUC-MSC）移植治疗早期股骨头坏死（ONFH）的效果。
回顾性分析了 18 例共 26 髋诊断为 Association Research Circulation Osseous 股骨头缺血性坏死 2 期的患者，他们接受了核心减压联合 hUC-MSC 移植。所有手术均在机器人辅助下完成。记录术前和术后视觉模拟评分（VAS）和 Harris 髋关节评分（HHS），以评估临床功能。最后一次随访时进行磁共振成像（MRI）检查。
平均随访 18.6 个月（12-28 个月），末次随访时 VAS 评分（4.5±0.8 比 0.9±0.2，t=12.6，p≤0.001）和 HHS（79.5±5.8 比 60.5±4.6，t=14.3，p≤0.001）均显著改善，与术前相比。MRI 结果显示股骨头坏死体积明显减少。
机器人辅助核心减压联合 hUC-MSC 移植是治疗股骨头坏死的一种可行且相对安全的方法。
