在坦桑尼亚，接受基于多替拉韦的抗逆转录病毒方案治疗的 HIV 感染儿童和青少年的依从性、疗效和安全性。
Adherence, Effectiveness and Safety of Dolutegravir Based Antiretroviral Regimens among HIV Infected Children and Adolescents in Tanzania.
机构信息
Department of Clinical Pharmacy and Pharmacology, School of Pharmacy, 92976Muhimbili University of Health and Allied Sciences, Dar es salaam, Tanzania.
Department of Pharmaceutics and Pharmacy practice, School of Pharmacy, 92976Muhimbili University of Health and Allied Sciences, Dar es salaam, Tanzania.
出版信息
J Int Assoc Provid AIDS Care. 2022 Jan-Dec;21:23259582221109613. doi: 10.1177/23259582221109613.
This study aimed at assessing adherence, effectiveness, and safety of DTG-based HAART regimens among HIV-infected children and adolescents in Tanzania. This was a single-center prospective cohort study, conducted at the pediatric HIV Clinic in Mbeya, Tanzania. A binary logistic regression model was used to determine predictors of undetectable viral load at week 24. The results were significant when P-value was <0.05. A total of 200 patients were enrolled with the majority (85.5%) being treatment experienced. High adherence levels (71%) were observed using the pharmacy refill method. At week 24, the overall proportion of patients with undetectable viral load was 70.2%. The predictors of undetectable viral load were age, World Health Organization (WHO) clinical stage, baseline VL and adherence to pharmacy refill. The majority of patients attained undetectable viral load 6 months after using DTG based regimen. DTG-based regimens were generally safe with few ADEs reported.
本研究旨在评估坦桑尼亚感染艾滋病毒的儿童和青少年中基于 DTG 的 HAART 方案的依从性、疗效和安全性。这是一项单中心前瞻性队列研究，在坦桑尼亚姆贝亚的儿科 HIV 诊所进行。使用二元逻辑回归模型来确定在第 24 周时病毒载量不可检测的预测因素。当 P 值 <0.05 时，结果具有统计学意义。共有 200 名患者入组，其中大多数（85.5%）为治疗经验丰富者。使用药房补药方法观察到较高的依从性水平（71%）。在第 24 周，总体上有 70.2%的患者病毒载量不可检测。病毒载量不可检测的预测因素是年龄、世界卫生组织（WHO）临床分期、基线 VL 和对药房补药的依从性。大多数患者在使用基于 DTG 的方案后 6 个月达到了不可检测的病毒载量。基于 DTG 的方案通常是安全的，报告的不良药物反应（ADEs）很少。
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