Department of Pharmaceutical Microbiology, 92976Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Department of Pharmacognosy,92976 Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
J Int Assoc Provid AIDS Care. 2022 Jan-Dec;21:23259582221084543. doi: 10.1177/23259582221084543.
Adherence to antiretroviral therapy (ART) is the key determinant of virological suppression in people living with HIV (PLHIV). This study reports factors associated with non-adherence among PLHIV one year after introducing dolutegravir (DTG) based regimens in Tanzania. A hospital-based cross-sectional study was conducted in two health facilities in Dar es Salaam, Tanzania, in 2020. A total of 406 PLHIV were recruited, where the majority (73.4%) were females, with 94.6% of patients being on DTG based regimens. Factors such as refill interval and sharing of antiretrovirals had significant effects on adherence. Multivariate analysis found that patients attending care and treatment center (CTC) at Temeke Regional Referral Hospital (RRH) were 4.3 times more likely to have non-adherence compared to those attending Amana RRH (aOR [adjusted odds ratio] 4.3, 95% CI [confidence interval]: 2.38 - 7.91, p-value < 0.0001). Sustainable adherence counseling is warranted to overcome non-adherence to ART.
抗逆转录病毒疗法（ART）的依从性是艾滋病毒感染者（PLHIV）病毒学抑制的关键决定因素。本研究报告了坦桑尼亚引入多替拉韦（DTG）为基础的方案一年后，与 PLHIV 不依从相关的因素。 2020 年，在坦桑尼亚达累斯萨拉姆的两家医疗机构进行了一项基于医院的横断面研究。共招募了 406 名 PLHIV，其中大多数（73.4%）为女性，94.6%的患者使用 DTG 为基础的方案。如续药间隔和抗逆转录病毒药物共享等因素对依从性有显著影响。多变量分析发现，与在 Amana RRH 就诊的患者相比，在 Temeke 区域转诊医院（RRH）就诊的患者不依从的可能性高 4.3 倍（调整后的优势比[aOR]4.3，95%置信区间[CI]：2.38-7.91，p 值<0.0001）。 需要进行可持续的依从性咨询，以克服对 ART 的不依从。
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