Department of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
STAR Protoc. 2022 Sep 16;3(3):101501. doi: 10.1016/j.xpro.2022.101501. Epub 2022 Jun 23.
Social observation facilitates spatial learning by activation of hippocampal place cell patterns. Here, we describe an observational spatial working memory task to investigate the neural circuits underlying observational learning. This approach trains observer rats to learn to run a T-maze by observing a demonstrator's spatial trajectory while recording their hippocampal CA1 place cell activities in a course of several hours. The protocol provides a tool to study neural activities at population level in a social setting. For complete details on the use and execution of this protocol, please refer to Mou et al. (2021).
社会观察通过激活海马体位置细胞模式促进空间学习。在这里，我们描述了一个观察性空间工作记忆任务，以研究观察学习背后的神经回路。这种方法训练观察者大鼠通过观察示教者的空间轨迹来学习跑 T 迷宫，同时在几个小时的过程中记录他们海马 CA1 位置细胞的活动。该方案为在社会环境中研究群体水平的神经活动提供了一种工具。如需详细了解本协议的使用和执行情况，请参阅 Mou 等人（2021 年）。
