Postgraduate Program in Nutrition and Health, Health Sciences Center, Federal University of Espírito Santo, Vitória, Espírito Santo, Brazil.
Department of Integrated Health Education, Health Sciences Center, Federal University of Espírito Santo, Vitória, Espírito Santo, Brazil.
PLoS One. 2022 Jul 1;17(7):e0270631. doi: 10.1371/journal.pone.0270631. eCollection 2022.
Handgrip strength (HGS) can be used to identify probable sarcopenia, by measuring maximum strength and/or through the average of three measurements. This study analyzed the agreement between maximum and mean HGS measurements in identifying probable sarcopenia in cancer patients.
Adult individuals of both sexes diagnosed with malignant neoplasm were evaluated. HGS (kg/f) was measured in both hands and nutritional status defined by the Patient-Generated Subjective Global Assessment (PG-SGA). Bland-Altman, Intraclass Correlation Coefficient (ICC), and Cronbach's Alpha tests were applied to assess the agreement between measurements.
One hundred forty-one patients aged 60.0 ± 14.2 years were evaluated. There was a predominance of elderly (57.4%), male (53.2%), and non-white (58.2%) individuals, with tumors located in the lower gastrointestinal tract (GIT) (36.9%) and with suspected or some degree of malnutrition (61.0%). For men, the Bland-Altman test showed a mean error of 1.37 (95% CI-1.03 to 3.80) for dominant HGS (DHGS) and 1.50 (95% CI-1.60 to 4.60) for non-dominant HGS (NDHGS), while for women the values were 1.34 (95% CI-0.27 to 2.95) and 1.14 (95% CI-1.10 to 3.39), respectively. The ICC showed excellent reproducibility (> 0.90) and the Cronbach's Alpha was satisfactory (0.99).
Despite the satisfactory agreement observed between maximum and mean HGS values, in this study, individuals of both sexes with probable sarcopenia were better identified through mean values.
通过测量最大力量和/或三次测量的平均值，握力（HGS）可用于识别疑似肌肉减少症。本研究分析了最大握力和平均握力测量值在识别癌症患者疑似肌肉减少症方面的一致性。
评估了诊断为恶性肿瘤的成年男女患者。分别测量双手的 HGS（kg/f），并通过患者生成的主观整体评估（PG-SGA）定义营养状况。应用 Bland-Altman、组内相关系数（ICC）和 Cronbach's Alpha 检验评估测量值之间的一致性。
共评估了 141 名 60.0±14.2 岁的患者。患者以老年人（57.4%）、男性（53.2%）和非白种人（58.2%）为主，肿瘤位于下胃肠道（GIT）（36.9%），且存在疑似或一定程度的营养不良（61.0%）。对于男性，Bland-Altman 检验显示，优势手 HGS（DHGS）的平均误差为 1.37（95%CI-1.03 至 3.80），非优势手 HGS（NDHGS）的平均误差为 1.50（95%CI-1.60 至 4.60），而对于女性，DHGS 的平均误差为 1.34（95%CI-0.27 至 2.95），NDHGS 的平均误差为 1.14（95%CI-1.10 至 3.39）。ICC 显示具有极好的可重复性（>0.90），Cronbach's Alpha 为可接受（0.99）。
尽管本研究中最大握力和平均握力值之间观察到了令人满意的一致性，但在男性和女性中，通过平均握力值能更好地识别疑似肌肉减少症患者。
