Caputo D, Zaffaroni M, Ghezzi A, Cazzullo C L
Acta Neurol Scand. 1987 Feb;75(2):84-6. doi: 10.1111/j.1600-0404.1987.tb07899.x.
Intrathecal IgG synthesis and CSF oligoclonal bands were reexamined after 18-24 months in 66 patients with multiple sclerosis; 40 of them received azathioprine (AZA) 2.5 mg/Kg/die; all received a course of dexamethasone (DEXA) during clinical relapses. The IgG Index was significantly reduced in the group treated with AZA, especially in patients with short disease duration, low disability and high IgG index. Changes observed in CSF banding pattern were not significant. These results suggest an effect of AZA on IgG synthesis, as reported by in vitro studies.
66例多发性硬化患者在18 - 24个月后重新检测了鞘内IgG合成和脑脊液寡克隆区带；其中40例接受硫唑嘌呤（AZA）2.5mg/（kg·天）治疗；所有患者在临床复发期间均接受了一个疗程的地塞米松（DEXA）治疗。接受AZA治疗的组中IgG指数显著降低，尤其是疾病病程短、残疾程度低且IgG指数高的患者。脑脊液条带模式的变化不显著。这些结果表明AZA对IgG合成有影响，正如体外研究所报道的那样。
