Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Radiology, Hubei No. 3 People's Hospital of Jianghan University, Wuhan, China.
Medicine (Baltimore). 2022 Jul 1;101(26):e29779. doi: 10.1097/MD.0000000000029779.
To investigate the feasibility of readout-segmented diffusion-weighted (rsDW) magnetic resonance (MR) in assessing nerve invasion of soft tissue tumor. Forty-four patients with soft tissue mass in upper leg suspected of nerve invasion underwent rsDW MR. Nerve invasion by tumor was rated by 2 radiologists, respectively. Sensitivity and specificity of rsDW MR in identifying nerve invasion were calculated, with operation findings as reference of standard. Apparent diffusion coefficient and fraction of anisotropy of nerve were obtained using DW MR, and then were compared between invaded nerves and noninvasion cases. Inter-reader agreement in using rsDW MR to rate nerve invasion was excellent (kappa = 0.891 ± 0.043, P < 0.001). Sensitivity and specificity of rsDW MR in identifying nerve invasion were 89% and 88%, respectively. Apparent diffusion coefficient was significantly higher in invaded nerves versus normal nerves (1.45 ± 0.67 × 10-3 mm2/s vs 1.39 ± 0.46 × 10-3 mm2/s, P < 0.05). Fraction of anisotropy was significantly lower in invaded nerves versus normal nerves (0.22 ± 0.11 vs 0.37 ± 0.13, P < .05). Readout-segmented DW MR was feasible in assessing sciatic nerve invasion by soft tissue tumor in selected patients.
为了研究读出分段弥散加权（rsDW）磁共振（MR）在评估软组织肿瘤神经侵犯中的可行性，对 44 例怀疑有神经侵犯的大腿软组织肿块患者进行了 rsDW MR 检查。2 名放射科医生分别对肿瘤的神经侵犯进行了评分。以手术结果为标准，计算 rsDW MR 识别神经侵犯的敏感性和特异性。通过 DW MR 获得神经的表观扩散系数和各向异性分数，并比较侵犯神经与无侵犯病例之间的差异。使用 rsDW MR 评估神经侵犯的两位读者之间的一致性非常好（kappa = 0.891±0.043，P < 0.001）。rsDW MR 识别神经侵犯的敏感性和特异性分别为 89%和 88%。侵犯神经的表观扩散系数明显高于正常神经（1.45±0.67×10-3mm2/s 比 1.39±0.46×10-3mm2/s，P < 0.05）。侵犯神经的各向异性分数明显低于正常神经（0.22±0.11 比 0.37±0.13，P < 0.05）。在选择的患者中，读出分段 DW MR 可用于评估软组织肿瘤对坐骨神经的侵犯。
