Department of Hematology, The First Affiliated Hospital of Guangxi Medical University, Guangxi, China.
Department of Hematology, Baise People's Hospital, Baise, Guangxi, China.
Medicine (Baltimore). 2022 Jul 1;101(26):e29756. doi: 10.1097/MD.0000000000029756.
Hodgkin lymphoma (HL)-related hemophagocytic lymphohistiocytosis (HLH) has been reported in the literature; however, there is almost no literature on the factors related to HL triggering HLH. One hundred forty patients with HL were retrospectively analyzed. The incidence of HL-related HLH (we call HL-related HLH as HL-HLH). And all HL-HLH patients in our cohort had HLH as the first manifestation and its clinical characteristics and the role of intrathoracic infection (ITI) in triggering HLH are discussed. The 140 patients with HL mainly included mixed-cellularity classic HL (MCCHL) in 81 (57.9%), nodular sclerosis classic HL (NSCHL) in 36 (25.7%), and lymphacyte-rich classic HL in 14 (10.0%) patients. Of the 137 patients who underwent chest computed tomography scans on admission, 44 had ITI, and most of these ITI were mildly ill and had no respiratory symptoms. Among 140 HL patients, 8 patients from MCCHL were diagnosed as HL-HLH. Among 81 MCCHL patients, 26 patients with ITI had a significantly higher incidence of HL-HLH than those without ITI (26.9% vs 1.8%, P = .002). The median survival time of 8 cases of HL-HLH was only 2 months. When HL patients were first admitted to the hospital, 5.7% had HLH as the first manifestation, and 32.1% had ITI. These ITI can cooperate with HL to trigger HLH, despite their mild illness. The prognosis of HL-HLH was poor.
霍奇金淋巴瘤（HL）相关噬血细胞性淋巴组织细胞增生症（HLH）在文献中有报道；然而，几乎没有关于与 HL 相关的触发 HLH 的因素的文献。回顾性分析了 140 例 HL 患者。HL 相关 HLH 的发生率（我们将 HL 相关 HLH 称为 HL-HLH）。在我们的队列中，所有 HL-HLH 患者均以 HLH 为首发表现，讨论其临床特征及胸内感染（ITI）在触发 HLH 中的作用。140 例 HL 患者主要包括混合细胞性经典 HL（MCCHL）81 例（57.9%）、结节硬化性经典 HL（NSCHL）36 例（25.7%）和富含淋巴细胞的经典 HL 14 例（10.0%）。137 例入院时行胸部 CT 扫描的患者中，44 例有 ITI，且多数 ITI 病情较轻，无呼吸道症状。在 140 例 HL 患者中，8 例 MCCHL 患者被诊断为 HL-HLH。在 81 例 MCCHL 患者中，26 例有 ITI 的患者 HL-HLH 的发生率明显高于无 ITI 的患者（26.9% vs 1.8%，P =.002）。8 例 HL-HLH 患者的中位生存时间仅为 2 个月。当 HL 患者首次入院时，有 5.7%以 HLH 为首发表现，有 32.1%有 ITI。尽管这些 ITI 病情较轻，但可与 HL 共同触发 HLH。HL-HLH 的预后较差。
