Department of Radiology, Gangnam Severance Hospital, Yonsei University College of Medicine, South Korea.
Department of Forensic Medicine, Yonsei University College of Medicine, South Korea.
Ann Anat. 2022 Oct;244:151974. doi: 10.1016/j.aanat.2022.151974. Epub 2022 Jun 29.
Here, we report the existence of dural channels in the parasagittal dural space and dura mater in humans. Microscopic mapping was performed to observe dural channels and arachnoid granulations in the whole dural tissue of nine individuals, and ultrastructural examinations and 3D micro-CT were used for further identification. The dural channels were concentrated along the parasagittal dural space regardless of the distribution of arachnoid granulations. Microscopically, they varied in size, presenting as distorted round-shaped empty spaces resembling mature fat vacuoles without subcellular structures. We found them to be lacking in the expression of lymphatic and vascular markers. 3D micro-CT revealed Swiss-cheese-like structured empty spaces connected to each other. Our findings show that dural channels are part of the anatomical structure of the parasagittal dural and space and dura mater. Although they are not the meningeal lymphatic vessels themselves, dural channels may serve as a reservoir of cerebrospinal fluid drainage.
在这里，我们报告了在人类矢状窦旁硬脑膜间隙和硬脑膜中存在硬脑膜通道的现象。我们进行了显微镜下的映射，以观察 9 个人的整个硬脑膜组织中的硬脑膜通道和蛛网膜颗粒，并使用超微结构检查和 3D 微 CT 进行进一步鉴定。硬脑膜通道集中在矢状窦旁硬脑膜间隙中，与蛛网膜颗粒的分布无关。在显微镜下，它们的大小不同，呈现出扭曲的圆形空泡状，类似于成熟的脂肪空泡，没有亚细胞结构。我们发现它们缺乏淋巴和血管标志物的表达。3D 微 CT 显示相互连接的瑞士奶酪状结构的空泡。我们的研究结果表明，硬脑膜通道是矢状窦旁硬脑膜和硬脑膜间隙的解剖结构的一部分。虽然它们本身不是脑膜淋巴管，但硬脑膜通道可能是脑脊液引流的储液器。
