Lin Zhijing, Yang Liyan, Chen Ping, Wei Tian, Zhang Jun, Wang Yan, Gao Lan, Zhang Cheng, Zhao Lingli, Wang Qunan, Wang Hua, Xu Dexiang
Department of Toxicology, School of Public Health, Anhui Medical University, Hefei 230032, China; Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Anhui Medical University, Hefei 230032, China.
Department of Toxicology, School of Public Health, Anhui Medical University, Hefei 230032, China.
Sci Total Environ. 2022 Oct 15;843:157000. doi: 10.1016/j.scitotenv.2022.157000. Epub 2022 Jun 28.
Growing literatures have explored the cardiorespiratory health effects of the daily temperature, but such effects of temperature variability remain unclear. We investigated the acute associations of personal levels of temperature variability with cardiorespiratory biomarkers. This is a panel study with four repeated measurements among forty eligible college students in Hefei, Anhui Province, China. We collected personal-level temperature data using temperature/humidity data loggers. Temperature variability parameters included diurnal temperature range (DTR), the standard-deviation of temperature (SDT) and temperature variability (TV). Cardiorespiratory health indicators included three BP parameters [systolic BP (SBP), diastolic BP (DBP) and mean article pressure (MAP)], fractional exhaled nitric oxide (FeNO), and four saliva biomarkers [C-reactive protein (CRP), cortisol, alpha-amylase and lysozyme]. Linear mixed-effect models were then used to assess the associations of temperature variability with these cardiorespiratory biomarkers. We found that short-term exposure to the three temperature variability parameters was associated with these cardiorespiratory biomarkers. The magnitude, direction and significance of these associations varied by temperature variability parameters, by biomarkers and by lags of exposure. Specifically, temperature variability parameters were inversely associated with BP and saliva lysozyme; positively associated with airway inflammation biomarkers (FeNO and saliva CRP) and stress response biomarkers (saliva cortisol and alpha-amylase). The results were robust to further control for air pollutants, and these associations were more prominent in females and in subjects with abnormal body mass index. Our findings suggested that acute exposure to temperature variability could significantly alter cardiorespiratory biomarker profiles among healthy young adults in China.
越来越多的文献探讨了每日气温对心肺健康的影响，但气温变异性的此类影响仍不明确。我们调查了个人气温变异性水平与心肺生物标志物之间的急性关联。这是一项在中国安徽省合肥市40名符合条件的大学生中进行的有四次重复测量的队列研究。我们使用温度/湿度数据记录器收集个人层面的温度数据。气温变异性参数包括日较差（DTR）、温度标准差（SDT）和温度变异性（TV）。心肺健康指标包括三个血压参数[收缩压（SBP）、舒张压（DBP）和平均动脉压（MAP）]、呼出一氧化氮分数（FeNO）以及四种唾液生物标志物[C反应蛋白（CRP）、皮质醇、α淀粉酶和溶菌酶]。然后使用线性混合效应模型评估气温变异性与这些心肺生物标志物之间的关联。我们发现，短期暴露于这三个气温变异性参数与这些心肺生物标志物有关。这些关联的程度、方向和显著性因气温变异性参数、生物标志物和暴露滞后时间而异。具体而言，气温变异性参数与血压和唾液溶菌酶呈负相关；与气道炎症生物标志物（FeNO和唾液CRP）以及应激反应生物标志物（唾液皮质醇和α淀粉酶）呈正相关。在进一步控制空气污染物后，结果依然稳健，且这些关联在女性和体重指数异常的受试者中更为突出。我们的研究结果表明，在中国健康的年轻成年人中，急性暴露于气温变异性可显著改变心肺生物标志物谱。
