Personal exposure to PM constituents associated with gestational blood pressure and endothelial dysfunction.

Ambient fine particulate matter (PM) pollution has been implicated in the development of hypertensive disorders of pregnancy. However, evidence on the effects of PM-derived chemical constituents on gestational blood pressure (BP) is limited, and the potential mechanisms underlying the association remain unclear. In this study, we repeated three consecutive 72-h personal air sampling and BP measurements in 215 pregnant women for 590 visits during pregnancy. Individual PM exposure level was assessed by gravimetric method and 28 PM chemical constituents were analyzed by ED-XRF method. Plasma biomarkers of endothelial function and inflammation were measured using multiplexed immunoassays. Robust multiple linear regression models were used to estimate the associations among personal PM exposure and chemical constituents, BP changes (compared with pre-pregnancy BP) and plasma biomarkers. Mediation analyses were performed to evaluate underlying potential pathways. Result showed that exposure to PM was significantly associated with increases in systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressure (MAP) in the early second trimester. Meanwhile, elevated concentration of lead (Pb) constituent in PM was significant associated with increases in DBP and MAP after adjusting for PM total mass. PM and Pb constituent also presented positive associations with plasma biomarkers of endothelial function (ET-1, E-selectin, ICAM-1) and inflammation (IL-1β, IL-6, TNFα) significantly. After multiple adjustment, elevated ET-1 and IL-6 were significantly correlated with increased gestational BP, and respectively mediated 1.24%-25.06% and 7.01%-10.69% of the increased BP due to PM and Pb constituent exposure. In conclusion, our results suggested that personal exposure to PM and Pb constituent were significantly associated with increased BP during pregnancy, and the early second trimester might be the sensitive window of PM exposure. The endothelial dysfunction and elevated inflammation partially mediated the effect of PM and Pb constituent on BP during pregnancy.