Department of Toxicology, School of Public Health, Anhui Medical University, Hefei, 230032, China.
Department of Toxicology, School of Public Health, Anhui Medical University, Hefei, 230032, China; Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Anhui Medical University, Hefei, 230032, China.
Environ Res. 2022 Nov;214(Pt 3):113983. doi: 10.1016/j.envres.2022.113983. Epub 2022 Aug 7.
Little is known about the acute health impacts of air quality index (AQI) on cardiorespiratory risk factors.
To assess the short-term links of AQI with cardiorespiratory risk factors in young healthy adults.
We performed a longitudinal panel study with 4 repeated visits in 40 healthy young adults in Hefei, Anhui Province, China from August to October 2021. Cardiorespiratory factors included systolic blood pressure (BP), diastolic BP (DBP), mean arterial pressure (MAP) and fractional exhaled nitric oxide (FeNO). We collected hourly AQI data from a nearby air quality monitoring site. Linear mixed-effects model was applied to assess the effects of AQI on BP and FeNO.
The study participants (75.0% females) provided 160 pairs of valid health measurements with average age of 24 years. The mean AQI level was 44.43 during the study period. There were significant positive associations of AQI with three BP parameters and FeNO at different lag periods. For example, an interquartile range increase in AQI (26.54 unit) over lag 0-24 h was associated with increments of 6.69 mmHg (95%CI: 2.95-10.44), 5.71 mmHg (95%CI: 3.30-8.13), 6.04 mmHg (95%CI: 3.46-8.62) and 5.67% (95%CI: 1.05%-16.05%) in SBP, DBP, MAP and FeNO, respectively. The results were robust after controlling for PM. We did not find effect modifications by gender, BMI, physical activity, or AQI category level on the associations.
The current findings on associations of AQI with cardiorespiratory factors might add evidence of the acute adverse cardiorespiratory consequences following air pollution.
人们对空气质量指数 (AQI) 对心肺风险因素的急性健康影响知之甚少。
评估 AQI 与年轻健康成年人心肺风险因素的短期关联。
我们在中国安徽省合肥市进行了一项纵向面板研究，共有 40 名健康的年轻成年人参加，从 2021 年 8 月至 10 月进行了 4 次重复访问。心肺相关因素包括收缩压 (BP)、舒张压 (DBP)、平均动脉压 (MAP) 和呼出气一氧化氮分数 (FeNO)。我们从附近的空气质量监测站收集了每小时的 AQI 数据。线性混合效应模型用于评估 AQI 对 BP 和 FeNO 的影响。
研究参与者（75.0%为女性）提供了 160 对有效的健康测量值，平均年龄为 24 岁。研究期间的平均 AQI 水平为 44.43。在不同的滞后期，AQI 与三个 BP 参数和 FeNO 呈显著正相关。例如，滞后 0-24 小时 AQI 每增加一个四分位距（26.54 个单位），SBP、DBP、MAP 和 FeNO 分别增加 6.69mmHg（95%CI：2.95-10.44）、5.71mmHg（95%CI：3.30-8.13）、6.04mmHg（95%CI：3.46-8.62）和 5.67%（95%CI：1.05%-16.05%）。在控制 PM 后，结果仍然稳健。我们没有发现性别、BMI、体力活动或 AQI 类别水平对这些关联的影响有调节作用。
目前关于 AQI 与心肺因素关联的研究结果可能为空气污染后急性不良心肺后果提供了证据。
