Solomon Sadie, Stachel Anna, Kelly Anne, Mraz Joe, Aguilar Peter, Gardner Julia, Medefindt Judith, Horrocks Amy, Sterling Stephanie, Aguero-Rosenfeld Maria, Phillips Michael
Department of Infection Prevention and Control, NYU Langone Health, New York, NY; Hospital Operations, NYU Langone Health, New York, NY.
Department of Infection Prevention and Control, NYU Langone Health, New York, NY.
Am J Infect Control. 2023 Apr;51(4):367-371. doi: 10.1016/j.ajic.2022.06.021. Epub 2022 Jun 29.
Sporicidal disinfectants are necessary to control Clostridioides difficile and Candida auris. Novel application methods such as electrostatic sprayers may increase disinfection effectiveness. We employed a standardized protocol to assess 3 sporicidal disinfectants: electrolyzed water (EW), sodium dichloroisocyanurate (NaDCC) and peracetic acid/hydrogen peroxide (PAA/HO).
The study was conducted at 2 New York City hospitals (1,082 total beds) over an 18-month period. The 3 chemicals were applied by housekeeping personnel following the hospital protocol; the use of electrostatic sprayers was incorporated into EW and NaDCC. In randomly selected rooms, 5 surfaces were sampled for microbial colony counts after cleaning. Data analyses were performed using negative binomial logistic regression.
We collected 774 samples. NaDCC-disinfected surfaces had a lower mean colony count (14 colony forming units [CFU]) compared to PAA/HO (18 CFU, P = .36) and EW (37 CFU, P < .001). PAA/HO and EW had more samples with any growth (both P < .05) compared to NaDCC. NaDCC applied with wipes and an electrostatic sprayer had the lowest number of samples with no growth and <2.5 CFU/cm (difference not significant).
The use of NaDCC for surface disinfection resulted in the lowest bacterial colony counts on patient room high touch surfaces in our study.
杀孢子消毒剂对于控制艰难梭菌和耳念珠菌很有必要。诸如静电喷雾器之类的新型应用方法可能会提高消毒效果。我们采用了标准化方案来评估三种杀孢子消毒剂：电解水（EW）、二氯异氰尿酸钠（NaDCC）和过氧乙酸/过氧化氢（PAA/HO）。
该研究在纽约市的两家医院（共1082张床位）进行，为期18个月。这三种化学物质由保洁人员按照医院规程进行应用；静电喷雾器的使用被纳入EW和NaDCC的应用中。在随机选择的房间里，清洁后对5个表面进行微生物菌落计数采样。使用负二项逻辑回归进行数据分析。
我们收集了774个样本。与PAA/HO（18个菌落形成单位[CFU]，P = 0.36）和EW（37个CFU，P < 0.001）相比，经NaDCC消毒的表面平均菌落数更低（14个CFU）。与NaDCC相比，PAA/HO和EW有更多有任何生长的样本（两者P < 0.05）。使用擦拭布和静电喷雾器应用NaDCC时，无生长且<2.5 CFU/cm的样本数量最少（差异不显著）。
在我们的研究中，使用NaDCC进行表面消毒在病房高接触表面上产生的细菌菌落数最低。
